Biomaterial Database

The pathogenetic role of free-circulating antibody in autologous immune complex glomerulonephritis. 1980

G J Fleuren, and J Grond, and P J Hoedemaeker

Autologous immune complex glomerulonephritis is an established model of chronic glomerulonephritis which very closely resembles membranous glomerulopathy in man. The disease can be induced in certain rat strains by immunization with tubular brush-border antigen (FxlA) in Freund's complete adjuvant. This procedure is believed to result in circulating immune complexes consisting of anti-FxlA antibody and FxlA antigen, which are deposited along the glomerular basement membrane. Since previous studies have indicated the presence of FxlA antigen in the glomerular basement membrane of normal rat and suggested an in situ formation of immune aggregates at this site as the pathogenetic mechanism in heterologous immune complex glomerulonephritis, the validity of the same mechanism in the pathogenesis of autologous immune complex glomerulonephritis was studied. In an investigation into the pathogenesis of the this model an association was found between the serum titre of autologous anti-FxlA antibody and the presence of immune aggregates in the glomerular basement membrane. Unilateral perfusion of normal kit kidneys with IgG eluted from kidneys of rats with autologous immune complex glomerulonephritis resulted in a binding of autologous anti-FxlA antibody at the subepithelial side of the glomerular basement membrane. These results indicate a pathogenetic role for circulating anti-FxlA antibody and demonstrate that rat anti-FxlA antibody is able to bind to FxlA antigens present in the glomerular basement membrane. Although these experiments do not exclude a possible role for circulating immune complexes, a pathogenetic mechanism of in situ formation of subepithelial immune aggregates in autologous immune complex glomerulonephritis is strongly suggested.

UI	MeSH Term	Description	Entries
D007105	Immune Complex Diseases	Group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides SERUM SICKNESS and the ARTHUS REACTION, evidence supports a pathogenic role for immune complexes in many other IMMUNE SYSTEM DISEASES including GLOMERULONEPHRITIS, systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC) and POLYARTERITIS NODOSA.	Hypersensitivity, Type III,Type III Hypersensitivity,Disease, Immune Complex,Diseases, Immune Complex,Hypersensitivities, Type III,Immune Complex Disease,Type III Hypersensitivities
D007116	Immunization, Passive	Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).	Convalescent Plasma Therapy,Immunoglobulin Therapy,Immunotherapy, Passive,Normal Serum Globulin Therapy,Passive Antibody Transfer,Passive Transfer of Immunity,Serotherapy,Passive Immunotherapy,Therapy, Immunoglobulin,Antibody Transfer, Passive,Passive Immunization,Therapy, Convalescent Plasma,Transfer, Passive Antibody
D007678	Kidney Glomerulus	A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.	Glomerulus, Kidney
D007684	Kidney Tubules	Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.	Kidney Tubule,Tubule, Kidney,Tubules, Kidney
D008854	Microscopy, Electron	Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.	Electron Microscopy
D008871	Microvilli	Minute projections of cell membranes which greatly increase the surface area of the cell.	Brush Border,Striated Border,Border, Brush,Border, Striated,Borders, Brush,Borders, Striated,Brush Borders,Microvillus,Striated Borders
D005260	Female		Females
D005921	Glomerulonephritis	Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.	Bright Disease,Kidney Scarring,Glomerulonephritides,Scarring, Kidney
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000937	Antigen-Antibody Reactions	The processes triggered by interactions of ANTIBODIES with their ANTIGENS.	Antigen Antibody Reactions,Antigen-Antibody Reaction,Reaction, Antigen-Antibody,Reactions, Antigen-Antibody