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Psychotropic drugs, especially neuroleptics, reversibly and noncompetitively inhibit the activity of Na, K-ATPase of the brain and Ca, Mg-ATPase of the sarcoplasmatic reticulum. The inhibitory effect is more pronounced versus the sarcoplasmatic reticulum and less marked versus purified enzymatic preparations. It is not much dependable on variations in the protein concentration of enzymatic preparations and is not related to drug binding to sulfhydryl groups of an enzyme. The inhibitory action of the drugs declines or completely disappears after treating the membranous preparations with phospholipase A. That psychotropic drugs have a predominant effect on the lipid structure of the membrane was supported during examination of EPR spectra of lipid spin labels.
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