-transparent.png){kind=logo}
After experimental studies in dogs confirmed the feasibility and safety of rapid intracoronary thrombolysis by local infusion of Thrombolysin (streptokinase and plasmin), intracoronary thrombolysis was attempted in 20 patients with evolving myocardial infarction who were hospitalized within 3 hours from the onset of symptoms during the day and within 2 hours at night. Thrombolysin was infused in the immediate vicinity of the site of coronary occlusion using a 0.85 mm outer diameter catheter advanced through the lumen of the Judkins catheter. Reperfusion was achieved in four patients after an average of 43 minutes of Thrombolysin infusion at a rate of 2000 IU/min and in 15 patients after an average of 21 minutes of Thrombolysin infusion at a rate of 4000 IU/min. The failure to open the artery in one patient may have been caused by our inability to advance the infusion catheter close to the site of occlusion. Rethrombosis occurred in one patient 8 days after reperfusion and 2 days after discontinuation of anticoagulants because of a history of chronic alcoholism. Wall motion and perfusion studies showed improvement following reperfusion. Patency of the artery was achieved an average of 4 hours after the onset of symptoms. The need for earlier reperfusion is emphasized.
W Ganz, and
N Buchbinder, and
H Marcus, and
A Mondkar, and
J Maddahi, and
Y Charuzi, and
L O'Connor, and
W Shell, and
M C Fishbein, and
R Kass, and
A Miyamoto, and
H J Swan
October 1981,
Annals of internal medicine,
W Ganz, and
N Buchbinder, and
H Marcus, and
A Mondkar, and
J Maddahi, and
Y Charuzi, and
L O'Connor, and
W Shell, and
M C Fishbein, and
R Kass, and
A Miyamoto, and
H J Swan
August 1984,
Arquivos brasileiros de cardiologia,
W Ganz, and
N Buchbinder, and
H Marcus, and
A Mondkar, and
J Maddahi, and
Y Charuzi, and
L O'Connor, and
W Shell, and
M C Fishbein, and
R Kass, and
A Miyamoto, and
H J Swan
November 1983,
Schweizerische medizinische Wochenschrift,
W Ganz, and
N Buchbinder, and
H Marcus, and
A Mondkar, and
J Maddahi, and
Y Charuzi, and
L O'Connor, and
W Shell, and
M C Fishbein, and
R Kass, and
A Miyamoto, and
H J Swan
December 1988,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
W Ganz, and
N Buchbinder, and
H Marcus, and
A Mondkar, and
J Maddahi, and
Y Charuzi, and
L O'Connor, and
W Shell, and
M C Fishbein, and
R Kass, and
A Miyamoto, and
H J Swan
September 1989,
Journal of cardiology,
W Ganz, and
N Buchbinder, and
H Marcus, and
A Mondkar, and
J Maddahi, and
Y Charuzi, and
L O'Connor, and
W Shell, and
M C Fishbein, and
R Kass, and
A Miyamoto, and
H J Swan
July 1988,
Japanese circulation journal,
W Ganz, and
N Buchbinder, and
H Marcus, and
A Mondkar, and
J Maddahi, and
Y Charuzi, and
L O'Connor, and
W Shell, and
M C Fishbein, and
R Kass, and
A Miyamoto, and
H J Swan
February 1984,
Presse medicale (Paris, France : 1983),
W Ganz, and
N Buchbinder, and
H Marcus, and
A Mondkar, and
J Maddahi, and
Y Charuzi, and
L O'Connor, and
W Shell, and
M C Fishbein, and
R Kass, and
A Miyamoto, and
H J Swan
January 1987,
Catheterization and cardiovascular diagnosis,
W Ganz, and
N Buchbinder, and
H Marcus, and
A Mondkar, and
J Maddahi, and
Y Charuzi, and
L O'Connor, and
W Shell, and
M C Fishbein, and
R Kass, and
A Miyamoto, and
H J Swan
August 1982,
Harefuah,
W Ganz, and
N Buchbinder, and
H Marcus, and
A Mondkar, and
J Maddahi, and
Y Charuzi, and
L O'Connor, and
W Shell, and
M C Fishbein, and
R Kass, and
A Miyamoto, and
H J Swan
December 1982,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
