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The effect of phosphonoacetic acid (PAA) on reproduction of vaccinia virus in chick embryo fibroblast cultures and on the development of vaccinia virus infection in rabbits was studied. In vitro the preparation was tested as a solution, in vivo as a solution and ointment. In rabbits, the preparation was applied epicutaneously and inoculated subcutaneously and intravenously. All these routes were found to be effective. A single application conferred a much lower protective effect than daily administration for 4 days. Poly (I).poly (C) administered subcutaneously was found to be more effective than PAA. The latter in tissue culture exerted a marked inhibiting effect when used in a dose of 100 microgram/ml.
O G Andzhaparide, and
T A Bektemirov, and
M P Burgasova, and
E V Chekunova
October 1979,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
O G Andzhaparide, and
T A Bektemirov, and
M P Burgasova, and
E V Chekunova
January 1982,
Virologie,
O G Andzhaparide, and
T A Bektemirov, and
M P Burgasova, and
E V Chekunova
March 1977,
The Journal of antimicrobial chemotherapy,
O G Andzhaparide, and
T A Bektemirov, and
M P Burgasova, and
E V Chekunova
August 1977,
The British journal of ophthalmology,
O G Andzhaparide, and
T A Bektemirov, and
M P Burgasova, and
E V Chekunova
February 1976,
The Journal of investigative dermatology,
O G Andzhaparide, and
T A Bektemirov, and
M P Burgasova, and
E V Chekunova
September 1973,
Applied microbiology,
O G Andzhaparide, and
T A Bektemirov, and
M P Burgasova, and
E V Chekunova
May 1976,
Infection and immunity,
O G Andzhaparide, and
T A Bektemirov, and
M P Burgasova, and
E V Chekunova
March 1975,
Antimicrobial agents and chemotherapy,
O G Andzhaparide, and
T A Bektemirov, and
M P Burgasova, and
E V Chekunova
May 1977,
Antimicrobial agents and chemotherapy,
O G Andzhaparide, and
T A Bektemirov, and
M P Burgasova, and
E V Chekunova
February 1976,
Antimicrobial agents and chemotherapy,
