-transparent.png){kind=logo}
The effect of Fominoben-HCl (Noleptan) was studied in male rats given 200 mg/kg/day over one, two or four weeks. In all three experiments a slight enlargement of the liver was observed. After one-week treatment, activity of microsomal mixed-function oxidase was stimulated without an increase in cytochrome P-450 content. After 2 or 4 weeks of treatment the activity of microsomal mixed-function oxidase expressed as the activity per microsomal protein remained unchanged. The fominoben-HCl-caused biochemical changes and the slight increase in organ weight of the liver were completely reversible within 2 weeks after cessation of treatment.
Related Publications
S Nakanishi, and
E Shiohara, and
M Tsukada, and
I Kawahara, and
R Matsumura, and
A Nagakura, and
H Kohei
November 1974,
Arzneimittel-Forschung,
S Nakanishi, and
E Shiohara, and
M Tsukada, and
I Kawahara, and
R Matsumura, and
A Nagakura, and
H Kohei
November 1974,
Arzneimittel-Forschung,
S Nakanishi, and
E Shiohara, and
M Tsukada, and
I Kawahara, and
R Matsumura, and
A Nagakura, and
H Kohei
January 1978,
Arzneimittel-Forschung,
S Nakanishi, and
E Shiohara, and
M Tsukada, and
I Kawahara, and
R Matsumura, and
A Nagakura, and
H Kohei
January 1979,
Arzneimittel-Forschung,
S Nakanishi, and
E Shiohara, and
M Tsukada, and
I Kawahara, and
R Matsumura, and
A Nagakura, and
H Kohei
January 1979,
Arzneimittel-Forschung,
S Nakanishi, and
E Shiohara, and
M Tsukada, and
I Kawahara, and
R Matsumura, and
A Nagakura, and
H Kohei
January 1976,
Arzneimittel-Forschung,
S Nakanishi, and
E Shiohara, and
M Tsukada, and
I Kawahara, and
R Matsumura, and
A Nagakura, and
H Kohei
July 1988,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
S Nakanishi, and
E Shiohara, and
M Tsukada, and
I Kawahara, and
R Matsumura, and
A Nagakura, and
H Kohei
February 1973,
Arzneimittel-Forschung,
S Nakanishi, and
E Shiohara, and
M Tsukada, and
I Kawahara, and
R Matsumura, and
A Nagakura, and
H Kohei
February 1973,
Arzneimittel-Forschung,
S Nakanishi, and
E Shiohara, and
M Tsukada, and
I Kawahara, and
R Matsumura, and
A Nagakura, and
H Kohei
November 2002,
Gastroenterologia y hepatologia,
