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Rat hypothalamic neurons were cultured in the presence of fluorodeoxyuridine to inhibit nonneuronal cell proliferation. Under these conditions, neuronal cell survival was dependent on contact with homologous nonneuronal cells. This phenomenon did not seem to be due to the release of diffusable trophic factors, since neither growth on polylysine in the close proximity of nonneuronal cells nor the use of preconditioned medium significantly increased neuronal survival. However, metabolically active cell layers were required, since growth on heat-killed or fixed homologous nonneuronal cells did not increase neuronal survival. The increased survival of neurons seen here in the presence of homologous nonneuronal cells therefore appears to be due to metabolic co-operation mediated by specific, direct cell-cell contact.
S A Whatley, and
C Hall, and
L Lim
December 1974,
Brain research,
S A Whatley, and
C Hall, and
L Lim
January 1974,
Neurobiology,
S A Whatley, and
C Hall, and
L Lim
April 1989,
Neuroscience letters,
S A Whatley, and
C Hall, and
L Lim
December 1987,
Brain research,
S A Whatley, and
C Hall, and
L Lim
June 1991,
Brain research. Developmental brain research,
S A Whatley, and
C Hall, and
L Lim
January 1984,
Cell and tissue research,
S A Whatley, and
C Hall, and
L Lim
December 1972,
Proceedings of the National Academy of Sciences of the United States of America,
S A Whatley, and
C Hall, and
L Lim
April 1991,
Neuroscience letters,
S A Whatley, and
C Hall, and
L Lim
January 1979,
International review of cytology,
S A Whatley, and
C Hall, and
L Lim
January 1986,
Neurotoxicology,
