-transparent.png){kind=logo}
The detailed kinetics of TCGF accumulation in Con A-stimulated spleen cell cultures shows a maximum at 24 hr, with a subsequent decrease in activity. This decrease is not due to the appearance of inhibitory substances "masking" TCGF activity. Pulse experiments show that the rate of TCGF production falls sharply after 18 hr and is completely arrested after 24 hr of Con A stimulation. The arrest in TCGF production is the result neither of culture depletion in medium components nor of limiting accessory cell function or inactivation of the lectin, and it thus seem to be the result of inactivation of TCGF-producing T cells. This regulation is not the result of a TCGF-mediated feedback mechanism but rather of lectin-induced suppressive cells that appear in culture after 24 hr and turn off de novo production of TCGF in fresh cultures.
M Gullberg, and
F Ivars, and
A Coutinho, and
E L Larsson
September 1987,
Cellular immunology,
M Gullberg, and
F Ivars, and
A Coutinho, and
E L Larsson
January 1984,
Critical reviews in immunology,
M Gullberg, and
F Ivars, and
A Coutinho, and
E L Larsson
May 1984,
Cellular immunology,
M Gullberg, and
F Ivars, and
A Coutinho, and
E L Larsson
October 1984,
Journal of biological response modifiers,
M Gullberg, and
F Ivars, and
A Coutinho, and
E L Larsson
January 1984,
Clinical and experimental immunology,
M Gullberg, and
F Ivars, and
A Coutinho, and
E L Larsson
February 1983,
Journal of immunological methods,
M Gullberg, and
F Ivars, and
A Coutinho, and
E L Larsson
February 1984,
No shinkei geka. Neurological surgery,
M Gullberg, and
F Ivars, and
A Coutinho, and
E L Larsson
January 1987,
Annales de l'Institut Pasteur. Immunology,
M Gullberg, and
F Ivars, and
A Coutinho, and
E L Larsson
June 1981,
Journal of immunology (Baltimore, Md. : 1950),
M Gullberg, and
F Ivars, and
A Coutinho, and
E L Larsson
January 1981,
Experimental cell biology,
