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In view of providing hepatic assistance, and for conservation aims in attempts at transplantation conditions have been investigated for achieving extracorporeal normothermal perfusion of the liver isolated from pig and dog. A total of 33 experiments have been performed. The preparations and the devices used allow to apply the method in a patient only after stabilisation of the perfusion, and frees the medical team from a series of technical problems. The duration and the quality of the perfusion are especially influenced by the collecting technique. In the dog the liver should be removed 3--5 hours, and in the pig 7--8 hours before perfusion is started. The functional condition of the liver can be assessed at 45 minutes after the start of the perfusion by evaluating the following criteria: the macroscopic aspect of the liver, the blood flow, the biliary flow, the ascitis fluid, TGP and oxygen consumption. Adequate installations and a permanent involvement of the laboratory team are essential conditions for the application of this method to the treatment of acute severe hepatic failure.
V Fluture, and
S Iliescu, and
A Dumitru, and
T Dinulescu, and
I Zahner, and
I Dan, and
P Auer, and
I Hell, and
E Hengelmann, and
M Neiss, and
A Chiru
January 1999,
Lancet (London, England),
V Fluture, and
S Iliescu, and
A Dumitru, and
T Dinulescu, and
I Zahner, and
I Dan, and
P Auer, and
I Hell, and
E Hengelmann, and
M Neiss, and
A Chiru
September 1976,
AMB : revista da Associacao Medica Brasileira,
V Fluture, and
S Iliescu, and
A Dumitru, and
T Dinulescu, and
I Zahner, and
I Dan, and
P Auer, and
I Hell, and
E Hengelmann, and
M Neiss, and
A Chiru
January 1973,
Acta medica Polona,
V Fluture, and
S Iliescu, and
A Dumitru, and
T Dinulescu, and
I Zahner, and
I Dan, and
P Auer, and
I Hell, and
E Hengelmann, and
M Neiss, and
A Chiru
February 1971,
The Australian and New Zealand journal of surgery,
V Fluture, and
S Iliescu, and
A Dumitru, and
T Dinulescu, and
I Zahner, and
I Dan, and
P Auer, and
I Hell, and
E Hengelmann, and
M Neiss, and
A Chiru
December 1970,
Langenbecks Archiv fur Chirurgie,
V Fluture, and
S Iliescu, and
A Dumitru, and
T Dinulescu, and
I Zahner, and
I Dan, and
P Auer, and
I Hell, and
E Hengelmann, and
M Neiss, and
A Chiru
September 1974,
Minerva chirurgica,
V Fluture, and
S Iliescu, and
A Dumitru, and
T Dinulescu, and
I Zahner, and
I Dan, and
P Auer, and
I Hell, and
E Hengelmann, and
M Neiss, and
A Chiru
March 1973,
Revista clinica espanola,
V Fluture, and
S Iliescu, and
A Dumitru, and
T Dinulescu, and
I Zahner, and
I Dan, and
P Auer, and
I Hell, and
E Hengelmann, and
M Neiss, and
A Chiru
June 1994,
Transplantation proceedings,
V Fluture, and
S Iliescu, and
A Dumitru, and
T Dinulescu, and
I Zahner, and
I Dan, and
P Auer, and
I Hell, and
E Hengelmann, and
M Neiss, and
A Chiru
July 1977,
Fortschritte der Medizin,
V Fluture, and
S Iliescu, and
A Dumitru, and
T Dinulescu, and
I Zahner, and
I Dan, and
P Auer, and
I Hell, and
E Hengelmann, and
M Neiss, and
A Chiru
December 1968,
Lancet (London, England),
