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Because aspirin and indomethacin, two structurally dissimilar anti-inflammatory agents which reduce prostaglandin synthesis, both alter renal function, we studied the effect on renal function of three new nonsteroidal anti-inflammatory drugs which also reduce prostaglandin synthesis. We have shown that ibuprofen, naproxen, and fenoprofen are able to reduce renal function in patients with systemic lupus erythematosus and that such changes are associated with reduced excretion of urinary prostaglandin E (PGE)-like compounds. The changes may attenuate despite continued drug administration. These findings emphasize that renal function must be assessed with caution in patients taking these and perhaps other drugs which inhibit prostaglandin synthesis.
R P Kimberly, and
R E Bowden, and
H R Keiser, and
P H Plotz
June 1988,
Journal of clinical pharmacology,
R P Kimberly, and
R E Bowden, and
H R Keiser, and
P H Plotz
June 1982,
East African medical journal,
R P Kimberly, and
R E Bowden, and
H R Keiser, and
P H Plotz
April 1994,
American family physician,
R P Kimberly, and
R E Bowden, and
H R Keiser, and
P H Plotz
April 1990,
Annals of internal medicine,
R P Kimberly, and
R E Bowden, and
H R Keiser, and
P H Plotz
September 1993,
Kidney international,
R P Kimberly, and
R E Bowden, and
H R Keiser, and
P H Plotz
January 1988,
Agents and actions. Supplements,
R P Kimberly, and
R E Bowden, and
H R Keiser, and
P H Plotz
January 1987,
Contributions to nephrology,
R P Kimberly, and
R E Bowden, and
H R Keiser, and
P H Plotz
April 2007,
Current allergy and asthma reports,
R P Kimberly, and
R E Bowden, and
H R Keiser, and
P H Plotz
June 1985,
The American journal of medicine,
R P Kimberly, and
R E Bowden, and
H R Keiser, and
P H Plotz
January 1993,
The Journal of surgical research,
