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The gastric secretory response to impromidine (SKF 92676), a potent selective histamine H2 agonist, has been studied in 40 patients with peptic ulcer disease or ulcer-like dyspepsia. Peak acid output following the intravenous infusion of impromidine, 10 micrograms kg-1h-1, or pentagastrin, 6 micrograms kg-1h-1, was not significantly different. This was also the case when the two drugs were administered subcutaneously at the same dose. Impromidine was well tolerated with only minor effects on the cardiovascular system both in 10 younger patients and in 20 subjects over the age of 55 years with mild to moderate cardiovascular disease. Impromidine can be considered an important tool for further investigation of the role of histamine at the H2-receptor site in man.
U Bangerter, and
M Schlup, and
M Liechti, and
W H Häcki, and
F Halter
October 1982,
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U Bangerter, and
M Schlup, and
M Liechti, and
W H Häcki, and
F Halter
March 1980,
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U Bangerter, and
M Schlup, and
M Liechti, and
W H Häcki, and
F Halter
April 1979,
British journal of clinical pharmacology,
U Bangerter, and
M Schlup, and
M Liechti, and
W H Häcki, and
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September 1979,
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U Bangerter, and
M Schlup, and
M Liechti, and
W H Häcki, and
F Halter
October 1986,
British journal of pharmacology,
U Bangerter, and
M Schlup, and
M Liechti, and
W H Häcki, and
F Halter
October 1985,
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U Bangerter, and
M Schlup, and
M Liechti, and
W H Häcki, and
F Halter
July 1981,
Gut,
U Bangerter, and
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F Halter
July 1982,
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U Bangerter, and
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F Halter
August 1981,
Life sciences,
U Bangerter, and
M Schlup, and
M Liechti, and
W H Häcki, and
F Halter
November 1978,
Nature,
