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We perfused in vitro the placentas of the mothers of 3 small for gestational age (SGA) and 3 adequate for gestational age (AGA) infants. After a systemic injection of 10 mg of dehydroepiandrosterone sulfate (DHEA-S), we measured the time course of the levels of DHEA-S, unconjugated DHEA, delta 4-androstenedione (delta 4-A), testosterone (T), estrone (E1) and estradiol (E2) in perfusate. We observed a significant accumulation of delta 4-A + T and a concomitant low increase of E1 + E2 in the placental fluid of SGA infants. We conclude that the aromatase activity could be decreased in some cases of placental insufficiency. This could, at least in part, explain the accumulation of circulating androgens in the mothers of some SGA infants following DHEA-S loading test observed in vivo.
H J Thoumsin, and
E Alsat, and
L Cedard
January 1973,
Annales d'endocrinologie,
H J Thoumsin, and
E Alsat, and
L Cedard
November 2000,
Alcohol (Fayetteville, N.Y.),
H J Thoumsin, and
E Alsat, and
L Cedard
October 1974,
Experientia,
H J Thoumsin, and
E Alsat, and
L Cedard
March 2004,
Hormones and behavior,
H J Thoumsin, and
E Alsat, and
L Cedard
July 1983,
Journal of steroid biochemistry,
H J Thoumsin, and
E Alsat, and
L Cedard
April 1994,
The Journal of reproductive medicine,
H J Thoumsin, and
E Alsat, and
L Cedard
June 1970,
Nederlandsch tijdschrift voor verloskunde en gynaecologie,
H J Thoumsin, and
E Alsat, and
L Cedard
March 1970,
Nederlands tijdschrift voor geneeskunde,
H J Thoumsin, and
E Alsat, and
L Cedard
December 1967,
Acta physiologica et pharmacologica Neerlandica,
H J Thoumsin, and
E Alsat, and
L Cedard
November 2004,
Seminars in reproductive medicine,
