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Detection of linkage between genetic loci in cattle has been hampered by the lack of large full -sib families. A unique source of full-sib families is now available from embryo transplantation. Lymphocytes from six full-sib families, ranging in size from three to seven siblings, were tested for serologically defined BoLA antigens (BoLA-A). In addition, mixed lymphocyte reactivity (MLR) was tested between all paired combinations of cells within each family to distinguish BoLA-D specificities. Serologically identical siblings within each family were reciprocally nonreactive in MLR, and vice versa; thus, no recombinants were detected between the BoLA-A and the BoLA-D loci. Classical genetic linkage analysis revealed that these loci are significantly closer than 11.9 centimorgans.
W R Usinger, and
M Curie-Cohen, and
K Benforado, and
D Pringnitz, and
R Rowe, and
G A Splitter, and
W H Stone
March 1977,
Transplantation proceedings,
W R Usinger, and
M Curie-Cohen, and
K Benforado, and
D Pringnitz, and
R Rowe, and
G A Splitter, and
W H Stone
December 1972,
The Journal of experimental medicine,
W R Usinger, and
M Curie-Cohen, and
K Benforado, and
D Pringnitz, and
R Rowe, and
G A Splitter, and
W H Stone
April 1973,
Nature: New biology,
W R Usinger, and
M Curie-Cohen, and
K Benforado, and
D Pringnitz, and
R Rowe, and
G A Splitter, and
W H Stone
January 1988,
Animal genetics,
W R Usinger, and
M Curie-Cohen, and
K Benforado, and
D Pringnitz, and
R Rowe, and
G A Splitter, and
W H Stone
September 1980,
Tissue antigens,
W R Usinger, and
M Curie-Cohen, and
K Benforado, and
D Pringnitz, and
R Rowe, and
G A Splitter, and
W H Stone
January 1973,
Tissue antigens,
W R Usinger, and
M Curie-Cohen, and
K Benforado, and
D Pringnitz, and
R Rowe, and
G A Splitter, and
W H Stone
January 1992,
Animal genetics,
W R Usinger, and
M Curie-Cohen, and
K Benforado, and
D Pringnitz, and
R Rowe, and
G A Splitter, and
W H Stone
December 1972,
Transplantation proceedings,
W R Usinger, and
M Curie-Cohen, and
K Benforado, and
D Pringnitz, and
R Rowe, and
G A Splitter, and
W H Stone
January 1977,
Tissue antigens,
W R Usinger, and
M Curie-Cohen, and
K Benforado, and
D Pringnitz, and
R Rowe, and
G A Splitter, and
W H Stone
January 1992,
Animal genetics,
