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The effect of sera from patients with Hodgkin's disease (HD) on monocyte dependent ConA and MLC-activation of normal lymphocytes to DNA synthesis was studied. Lymphocyte stimulation was greatly enhanced in the presence of monocytes at a monocyte : lymphocyte ratio of less than or equal to 8 : 1. Higher ratios were usually suppressive. Some HD sera suppressed monocyte mediated enhancement of ConA and MLC-stimulation efficiently. The degree of inhibition by the individual HD serum remained similar in the absence of monocytes and at various monocyte : lymphocyte ratios. Pretreatment of monocytes or lymphocytes with HD serum had no effect. Inhibition was only noted when serum was present during the whole culture period. It is concluded that HD sera do not hamper the activity of monocytes to augment lymphocyte growth. The effect may be explained by direct effects of serum factors on lymphocytes.
G Holm, and
M Björkholm, and
H Mellstedt, and
P Nilsson
October 1982,
Journal of clinical immunology,
G Holm, and
M Björkholm, and
H Mellstedt, and
P Nilsson
June 1972,
Cancer,
G Holm, and
M Björkholm, and
H Mellstedt, and
P Nilsson
July 1986,
The American journal of tropical medicine and hygiene,
G Holm, and
M Björkholm, and
H Mellstedt, and
P Nilsson
November 1994,
Clinical immunology and immunopathology,
G Holm, and
M Björkholm, and
H Mellstedt, and
P Nilsson
January 1987,
Folia haematologica (Leipzig, Germany : 1928),
G Holm, and
M Björkholm, and
H Mellstedt, and
P Nilsson
April 1991,
Indian journal of experimental biology,
G Holm, and
M Björkholm, and
H Mellstedt, and
P Nilsson
April 1984,
Journal of immunology (Baltimore, Md. : 1950),
G Holm, and
M Björkholm, and
H Mellstedt, and
P Nilsson
January 1989,
The British veterinary journal,
G Holm, and
M Björkholm, and
H Mellstedt, and
P Nilsson
March 1980,
Cancer,
G Holm, and
M Björkholm, and
H Mellstedt, and
P Nilsson
October 1984,
International journal of cancer,
