Biomaterial Database

[Effect of the surface-active substance N-cetylpyridinium chloride on the biosynthetic capacity of Brevibacterium ammoniagenes ATCC 6872, a producer of NAD]. 1984

N M Bazdyreva, and L S Kutseva

The effect of cetylpyridinium chloride (CPC), a cationic detergent, on the biosynthetic ability of the well known synthesizor of nucleotides Brevibacterium ammoniagenes ATCC 6872 was studied. It was found that CPC increasing the cell permeability affects also the cell carbohydrate metabolism. At the definite ratio of CPC and biomass which depends on the composition of the incubating medium, a maximum formation of pentoses occurs that is of great importance for obtaining NAD from the exogeneous precursors: nicotinamide and adenine. To obtain a high yield of pentoses and NAD, a short-term treatment of cells with CPC is sufficient.

UI	MeSH Term	Description	Entries
D009243	NAD	A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)	Coenzyme I,DPN,Diphosphopyridine Nucleotide,Nadide,Nicotinamide-Adenine Dinucleotide,Dihydronicotinamide Adenine Dinucleotide,NADH,Adenine Dinucleotide, Dihydronicotinamide,Dinucleotide, Dihydronicotinamide Adenine,Dinucleotide, Nicotinamide-Adenine,Nicotinamide Adenine Dinucleotide,Nucleotide, Diphosphopyridine
D010429	Pentoses	Monosaccharide sugar molecules that contain a five carbon backbone.	Pentose,Ketopentose,Ketopentoses
D011726	Pyridinium Compounds	Derivatives of PYRIDINE containing a cation C5H5NH or radical C5H6N.	Compounds, Pyridinium
D001951	Brevibacterium	A gram-positive organism found in dairy products, fresh and salt water, marine organisms, insects, and decaying organic matter.
D002594	Cetylpyridinium	Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges.	Angifonil,Biosept,Catamium,Ceepryn Chloride,Cetamium,Cetylpyridinium Chloride,Cetylpyridinium Chloride Anhydrous,Cetylpyridium,Cetylyre,Dobendan,Hexadecylpyridinium,Merocets,Pristacin,Pyrisept,Sterogenol,Anhydrous, Cetylpyridinium Chloride,Chloride Anhydrous, Cetylpyridinium,Chloride, Ceepryn,Chloride, Cetylpyridinium
D003470	Culture Media	Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.	Media, Culture
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D050260	Carbohydrate Metabolism	Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.	Metabolism, Carbohydrate