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The state of the steroidogenic function of the adrenal glands, lipid spectrum of the adrenal gland tissue and metabolism rate of 11-oxycorticosteroids (11-OCS) in the liver tissue and their levels in the blood plasma were studied on rats after a single administration of karminomycin in a dose of LD50 (1.55 mg/kg). The hormones of the adrenal cortex were shown to play a definite role in the mechanism of the karminomycin damaging effect. Dependence of the changes on the time of the drug effect was noted. The shifts were of a reversible character. No direct toxic damages in the tissue of the adrenal glands were observed. Only an increase in the 11-OCS blood levels and a decrease in the steroid metabolism in the liver tissue were shown. The latter must be due to the direct cytotoxic effect of karminomycin on the tissue of this organ.
N P Chuchalina, and
E D Gol'dberg, and
B Iu Sal'nik, and
V A Telesheva
January 1974,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
N P Chuchalina, and
E D Gol'dberg, and
B Iu Sal'nik, and
V A Telesheva
January 1989,
Proceedings of the National Academy of Sciences of the United States of America,
N P Chuchalina, and
E D Gol'dberg, and
B Iu Sal'nik, and
V A Telesheva
January 1968,
Zeitschrift fur Krebsforschung,
N P Chuchalina, and
E D Gol'dberg, and
B Iu Sal'nik, and
V A Telesheva
December 1952,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
N P Chuchalina, and
E D Gol'dberg, and
B Iu Sal'nik, and
V A Telesheva
January 1964,
Experientia,
N P Chuchalina, and
E D Gol'dberg, and
B Iu Sal'nik, and
V A Telesheva
January 1967,
Krebsforschung und Krebsbekampfung,
N P Chuchalina, and
E D Gol'dberg, and
B Iu Sal'nik, and
V A Telesheva
January 1963,
Chemotherapia,
N P Chuchalina, and
E D Gol'dberg, and
B Iu Sal'nik, and
V A Telesheva
January 1962,
Therapeutische Berichte,
N P Chuchalina, and
E D Gol'dberg, and
B Iu Sal'nik, and
V A Telesheva
January 1968,
Patologicheskaia fiziologiia i eksperimental'naia terapiia,
N P Chuchalina, and
E D Gol'dberg, and
B Iu Sal'nik, and
V A Telesheva
April 1965,
Antibiotiki,
