Occurrence of circulating immune complexes in beta-thalassaemia major. 1978

P Casali, and P Borzini, and D Vergani, and G Mieli-Vergani, and G Masera, and C Zanussi

The presence of circulating soluble immune complexes and the level of complement were investigated in sera from 21 patients with beta-thalassaemia major, including both splenectomised and nonsplenectomised patients. A high level of immune complexes was found in half of these cases. Reduced complement levels were seen less frequently. There was no correlation between the presence of circulating immune complexes, decreased complement levels, and thpresence or absence of the spleen. The level of immune complexes increased with the age ofthe individual, i.e. with the duration of the disease.

UI MeSH Term Description Entries
D008297 Male Males
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D003165 Complement System Proteins Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY). Complement Proteins,Complement,Complement Protein,Hemolytic Complement,Complement, Hemolytic,Protein, Complement,Proteins, Complement,Proteins, Complement System
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000367 Age Factors Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time. Age Reporting,Age Factor,Factor, Age,Factors, Age
D000936 Antigen-Antibody Complex The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES. Immune Complex,Antigen-Antibody Complexes,Immune Complexes,Antigen Antibody Complex,Antigen Antibody Complexes,Complex, Antigen-Antibody,Complex, Immune,Complexes, Antigen-Antibody,Complexes, Immune
D013156 Splenectomy Surgical procedure involving either partial or entire removal of the spleen. Splenectomies
D013789 Thalassemia A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia. Thalassemias

Related Publications

P Casali, and P Borzini, and D Vergani, and G Mieli-Vergani, and G Masera, and C Zanussi
June 1987, Clinical and experimental immunology,
P Casali, and P Borzini, and D Vergani, and G Mieli-Vergani, and G Masera, and C Zanussi
October 1998, Journal of tropical pediatrics,
P Casali, and P Borzini, and D Vergani, and G Mieli-Vergani, and G Masera, and C Zanussi
February 1978, Atherosclerosis,
P Casali, and P Borzini, and D Vergani, and G Mieli-Vergani, and G Masera, and C Zanussi
January 1979, Clinical and laboratory haematology,
P Casali, and P Borzini, and D Vergani, and G Mieli-Vergani, and G Masera, and C Zanussi
January 1989, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
P Casali, and P Borzini, and D Vergani, and G Mieli-Vergani, and G Masera, and C Zanussi
November 2001, Indian journal of pediatrics,
P Casali, and P Borzini, and D Vergani, and G Mieli-Vergani, and G Masera, and C Zanussi
January 1985, Acta haematologica,
P Casali, and P Borzini, and D Vergani, and G Mieli-Vergani, and G Masera, and C Zanussi
September 1983, Australian paediatric journal,
P Casali, and P Borzini, and D Vergani, and G Mieli-Vergani, and G Masera, and C Zanussi
December 1979, Archives of disease in childhood,
P Casali, and P Borzini, and D Vergani, and G Mieli-Vergani, and G Masera, and C Zanussi
May 1979, Journal of clinical pathology,
Copied contents to your clipboard!