Biomaterial Database

A study of liver microsomal enzymes in rats following propoxur (Baygon) administration. 1984

D L Nelson, and D W Lamb, and F Mihail

Groups of rats were given either propoxur, were left as untreated controls, or were given phenobarbital, DDT, chlordane or toxaphene which are known to induce liver microsomal detoxification enzymes. Microsomal enzyme activity was measured by testing the ability of liver homogenates to degrade EPN (O-ethyl O-(4-nitrophenyl) phenylphosphonothioate) to p-nitrophenol. The activity of aminopyrine-N-demethylase, cytochrome P-450 and p-nitroanisole-O-demethylase in liver homogenates of rats receiving propoxur was measured. Liver microsomal detoxification enzymes were not induced by propoxur exposure.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008862	Microsomes, Liver	Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.	Liver Microsomes,Liver Microsome,Microsome, Liver
D009575	Nitroanisole O-Demethylase	Oxidative enzyme which transforms p-nitroanisole into p-nitrophenol.	Nitroanisole O Demethylase,Demethylase, Nitroanisole O,O Demethylase, Nitroanisole,O-Demethylase, Nitroanisole
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D010634	Phenobarbital	A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.	Phenemal,Phenobarbitone,Phenylbarbital,Gardenal,Hysteps,Luminal,Phenobarbital Sodium,Phenobarbital, Monosodium Salt,Phenylethylbarbituric Acid,Acid, Phenylethylbarbituric,Monosodium Salt Phenobarbital,Sodium, Phenobarbital
D011919	Rats, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.	August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D003577	Cytochrome P-450 Enzyme System	A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.	Cytochrome P-450,Cytochrome P-450 Enzyme,Cytochrome P-450-Dependent Monooxygenase,P-450 Enzyme,P450 Enzyme,CYP450 Family,CYP450 Superfamily,Cytochrome P-450 Enzymes,Cytochrome P-450 Families,Cytochrome P-450 Monooxygenase,Cytochrome P-450 Oxygenase,Cytochrome P-450 Superfamily,Cytochrome P450,Cytochrome P450 Superfamily,Cytochrome p450 Families,P-450 Enzymes,P450 Enzymes,Cytochrome P 450,Cytochrome P 450 Dependent Monooxygenase,Cytochrome P 450 Enzyme,Cytochrome P 450 Enzyme System,Cytochrome P 450 Enzymes,Cytochrome P 450 Families,Cytochrome P 450 Monooxygenase,Cytochrome P 450 Oxygenase,Cytochrome P 450 Superfamily,Enzyme, Cytochrome P-450,Enzyme, P-450,Enzyme, P450,Enzymes, Cytochrome P-450,Enzymes, P-450,Enzymes, P450,Monooxygenase, Cytochrome P-450,Monooxygenase, Cytochrome P-450-Dependent,P 450 Enzyme,P 450 Enzymes,P-450 Enzyme, Cytochrome,P-450 Enzymes, Cytochrome,Superfamily, CYP450,Superfamily, Cytochrome P-450,Superfamily, Cytochrome P450
D004790	Enzyme Induction	An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.	Induction, Enzyme
D004849	Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester	An organothiophosphorus cholinesterase inhibitor that is used as an insecticide and as a acaricide.	ENT-17,798,EPN-300,O-Ethyl-O-(4-nitrophenyl)phenylphosphonothioate,ENT 17,798,ENT17,798,EPN 300,EPN300
D005260	Female		Females

Related Publications

D L Nelson, and D W Lamb, and F Mihail

[Changes in the serum activity of lysosome enzymes in rats after application of the insecticide propoxur (Baygon)].

January 1975, Problemi na khigienata,

D L Nelson, and D W Lamb, and F Mihail

Propoxur induced pancreatitis after inhalation of baygon pesticide.

April 2007, Pancreas,

D L Nelson, and D W Lamb, and F Mihail

Postnatal stimulation of hepatic microsomal enzymes following administration of TCDD to pregnant rats.

July 1975, Chemico-biological interactions,

D L Nelson, and D W Lamb, and F Mihail

[Studies on the behavior of microsomal enzymes in the rat liver following galactosamine administration].

January 1971, Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,

D L Nelson, and D W Lamb, and F Mihail

Effect of nicotinamide administration to rats on the liver microsomal drug metabolizing enzymes.

January 1983, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,

D L Nelson, and D W Lamb, and F Mihail

[Changes in the serum activity of lysosomal enzymes in rats after the use of propoxur (Baygon) insecticide. 2. The dynamics of beta-N-acetylglucosaminidase].

January 1976, Problemi na khigienata,

D L Nelson, and D W Lamb, and F Mihail

Stability study of propoxur (Baygon) in whole blood and urine stored at varying temperature conditions.

June 2006, Journal of analytical toxicology,

D L Nelson, and D W Lamb, and F Mihail

[Changes in the activity o some microsomal liver enzymes following phalloidin poisoning in rats].

August 1969, Hoppe-Seyler's Zeitschrift fur physiologische Chemie,

D L Nelson, and D W Lamb, and F Mihail

The experimental obstructive jaundice and liver microsomal enzymes in rats.

January 1971, Annales chirurgiae et gynaecologiae Fenniae,