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Serum theophylline concentration was measured in children both during treatment of status asthmaticus with intravenous aminophylline, and as outpatients while they were taking oral theophylline compounds for long-term management of asthma. The clinical value of the measurements was assessed. Measurement using high-pressure liquid chromatography is simple and requires only a small volume of blood. Knowledge of serum theophylline concentration facilitates careful control of dosage of both intravenous aminophylline during treatment of status asthmaticus, and of oral theophylline in outpatients. It is useful in the evaluation of symptoms which may be due to toxic side effects of treatment. It also makes possible an assessment of patient compliance with prescribed treatment among those whose symptoms have not improved.
S A McKenzie, and
A T Edmunds, and
E Baillie, and
J H Meek
June 1976,
Clinical chemistry,
S A McKenzie, and
A T Edmunds, and
E Baillie, and
J H Meek
November 1981,
Clinical chemistry,
S A McKenzie, and
A T Edmunds, and
E Baillie, and
J H Meek
November 1975,
Clinical chemistry,
S A McKenzie, and
A T Edmunds, and
E Baillie, and
J H Meek
October 1976,
British journal of clinical pharmacology,
S A McKenzie, and
A T Edmunds, and
E Baillie, and
J H Meek
October 1974,
The Journal of laboratory and clinical medicine,
S A McKenzie, and
A T Edmunds, and
E Baillie, and
J H Meek
November 1982,
Der Internist,
S A McKenzie, and
A T Edmunds, and
E Baillie, and
J H Meek
June 1976,
Journal of pharmaceutical sciences,
S A McKenzie, and
A T Edmunds, and
E Baillie, and
J H Meek
September 1979,
Journal of pharmaceutical sciences,
S A McKenzie, and
A T Edmunds, and
E Baillie, and
J H Meek
March 1979,
Toxicological European research. Recherche europeenne en toxicologie,
S A McKenzie, and
A T Edmunds, and
E Baillie, and
J H Meek
February 1979,
Annals of allergy,
