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The influence of chicken leukocyte interferon (IFN) on the antibody-dependent cellular cytotoxicity (ADCC) of peripheral blood mononuclear cells of chickens has been investigated in vivo and in vitro. The cytotoxic effect was studied on sheep red blood cells (SRBC) coated with chicken anti-SRBC serum. Cytotoxicity was estimated using a 51Cr release assay system. A single intravenous injection of crude IFN led to an enhanced ADCC 6 to 12 h after the IFN injection, whereas by 24 h the activity had decreased. The ability of IFN to augment the cytotoxicity was not lost after phagocytic cell depletion. In vitro, the ADCC was boosted within 1-18 h by IFN, in a dose-dependent manner. We assume that the augmenting agent in vitro is IFN itself, as purified IFN had a similar activity, but mock IFN and trypsin-treated IFN showed no enhancing effect.
Y Mándi, and
M Bakay, and
I Béládi
October 1981,
Journal of immunology (Baltimore, Md. : 1950),
Y Mándi, and
M Bakay, and
I Béládi
October 1974,
Journal of immunology (Baltimore, Md. : 1950),
Y Mándi, and
M Bakay, and
I Béládi
January 1999,
Methods in molecular medicine,
Y Mándi, and
M Bakay, and
I Béládi
January 2018,
Journal of theoretical biology,
Y Mándi, and
M Bakay, and
I Béládi
January 1981,
Reumatologia,
Y Mándi, and
M Bakay, and
I Béládi
January 1981,
Archivum immunologiae et therapiae experimentalis,
Y Mándi, and
M Bakay, and
I Béládi
July 1977,
Orvosi hetilap,
Y Mándi, and
M Bakay, and
I Béládi
June 1976,
Transplantation,
Y Mándi, and
M Bakay, and
I Béládi
January 1991,
Schweizer Archiv fur Neurologie und Psychiatrie (Zurich, Switzerland : 1985),
Y Mándi, and
M Bakay, and
I Béládi
January 2019,
Frontiers in immunology,
