Biomaterial Database

Growth of regenerating skeletal muscle fibers in cats. 1984

L C Maxwell, and J A Faulkner, and T P White, and F M Hansen-Smith

Extensor digitorum longus (EDL) muscles of cats were grafted heterotopically or orthotopically, and either with or without prior denervation. The autografted muscles were studied at times from 4 to 518 days after grafting. Muscle weight, fiber cross-sectional area, and ultrastructural, histochemical, and biochemical characteristics of regenerating muscle fibers were determined. Prior denervation reduced the mass of muscle at the time of grafting, but had no significant effect on the characteristics of the regenerating muscles. Orthotopic and heterotopic autografts achieved similar recovery of structure. Mean fiber area reached control values. Differentiation into fiber types occurred, but compared to control muscles, autografts had fewer Type I and Type IIA fibers. Electron microscopic analysis of regenerating muscle fibers revealed centrally located nuclei, but otherwise normal ultrastructure. The bimodal distribution of Z-band width was consistent with differentiation into fiber types. Mean data of some morphological variables did not stabilize.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009132	Muscles	Contractile tissue that produces movement in animals.	Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D012038	Regeneration	The physiological renewal, repair, or replacement of tissue.	Endogenous Regeneration,Regeneration, Endogenous,Regenerations
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia