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The soluble cAMP-dependent protein kinase activities of two estrogen receptor-containing (MCF-7 and ZR-75-1) and two estrogen receptor-lacking (BT-20 and MDA-MB-231) established human mammary tumor cell lines were analyzed by DEAE-cellulose chromatography and photoaffinity labeling with 8-azido-[32P]cAMP. Predominantly, type I isoenzyme was present in MDA-MB-231 cells, type II protein kinase was the main form in ZR-75-1 and BT-20 cells; whereas MCF-7 cytosols contained equal amounts of both protein kinase types. No correlations between estrogen receptor content and cAMP-dependent protein kinase holoenzyme ratios of isoenzymes were found. A distinctly greater heterogeneity of charge isomers of cAMP-binding proteins (regulatory subunits) was observed in estrogen receptor-containing cells.
W Küng, and
D Fabbro, and
K Handloser, and
U Eppenberger
March 1977,
Cell,
W Küng, and
D Fabbro, and
K Handloser, and
U Eppenberger
February 1994,
European journal of biochemistry,
W Küng, and
D Fabbro, and
K Handloser, and
U Eppenberger
January 1984,
Archives of gynecology,
W Küng, and
D Fabbro, and
K Handloser, and
U Eppenberger
November 1991,
Archives of biochemistry and biophysics,
W Küng, and
D Fabbro, and
K Handloser, and
U Eppenberger
June 1997,
Biochimica et biophysica acta,
W Küng, and
D Fabbro, and
K Handloser, and
U Eppenberger
August 1988,
European journal of cell biology,
W Küng, and
D Fabbro, and
K Handloser, and
U Eppenberger
February 1994,
Molecular and cellular endocrinology,
W Küng, and
D Fabbro, and
K Handloser, and
U Eppenberger
September 1986,
Biochemistry,
W Küng, and
D Fabbro, and
K Handloser, and
U Eppenberger
January 2001,
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie,
W Küng, and
D Fabbro, and
K Handloser, and
U Eppenberger
June 1988,
Cancer letters,
