The morphogenesis of the diffuse cardiosclerosis in chronic coronary heart disease (CHD) in connection with the microcirculatory alterations has been studied. 16 cardiobiopsies taken during the aortocoronary shunt operations and the heart of 15 rabbits fed atherogenic diet (0.25 g/kg cholesterol) for 8 weeks and at the same time given pituitrin every day at the dose level of 0.2 U/kg were examined. It is established that disorganization of the transporttrophic tissue supply stimulates desmoplastic processes. Protein-glycosaminoglycane complexes that are difficult to eliminate are formed in the interstitium with the participation of stromal cells; these complexes fill the loop-like constructions of the basic amorphous substance, are precipitated on the fibrillar structures influencing the permeability of stroma and its neoformation. Pathological changes in the interstitium structure are brought about in spite of the desmolithic reaction in which an express and lasting components may be distinguished. The most important element of diffuse cardiosclerosis in CHD is "vasophilic" orientation of fibroblasts leading to the formation of an additional barrier immediately arount blood capillaries.