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The phosphorylation of rabbit liver microsomal cytochrome P-450 LM2 by catalytic subunit of cyclic AMP-dependent protein kinase (W. Pyerin et al. (1983) Carcinogenesis 4, 573) has now been studied in detail with purified soluble form of cytochrome P-450 as well as with the purified protein incorporated into model membranes. The apparent Km values for P-450 of the phosphorylation reaction in all experimental systems were in a range of 2-8 microM, while the Vmax values were dependent on the state of P-450. Upon phosphorylation, the reconstituted enzyme activities with benzphetamine (N-demethylation) and 7-ethoxycoumarin (O-deethylation) as substrates were reduced to 30-40% of control.
W Pyerin, and
H Taniguchi, and
A Stier, and
F Oesch, and
C R Wolf
March 1986,
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry,
W Pyerin, and
H Taniguchi, and
A Stier, and
F Oesch, and
C R Wolf
January 1983,
Carcinogenesis,
W Pyerin, and
H Taniguchi, and
A Stier, and
F Oesch, and
C R Wolf
January 1988,
FEBS letters,
W Pyerin, and
H Taniguchi, and
A Stier, and
F Oesch, and
C R Wolf
January 1983,
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry,
W Pyerin, and
H Taniguchi, and
A Stier, and
F Oesch, and
C R Wolf
September 1982,
Biokhimiia (Moscow, Russia),
W Pyerin, and
H Taniguchi, and
A Stier, and
F Oesch, and
C R Wolf
January 1983,
Zeitschrift fur medizinische Laboratoriumsdiagnostik,
W Pyerin, and
H Taniguchi, and
A Stier, and
F Oesch, and
C R Wolf
January 1988,
Biomedica biochimica acta,
W Pyerin, and
H Taniguchi, and
A Stier, and
F Oesch, and
C R Wolf
January 1989,
Nauchnye doklady vysshei shkoly. Biologicheskie nauki,
W Pyerin, and
H Taniguchi, and
A Stier, and
F Oesch, and
C R Wolf
January 1994,
Voprosy pitaniia,
W Pyerin, and
H Taniguchi, and
A Stier, and
F Oesch, and
C R Wolf
July 1991,
Biokhimiia (Moscow, Russia),
