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Technetium-99m labeled bis(1,2-diethylphosphino)ethane was evaluated as a cardiac perfusion agent in mice, dogs and normal human volunteers. The agent produced as a single cationic compound was prepared by a simple kit type method and had a rapid myocardial uptake in animals. The cardiac uptake of the agent in dogs averaged 4.6% of administered dose and delineated left and right ventricles by in vivo imaging. In dogs with experimental myocardial infarction, the agent was distributed according to the regional myocardial blood flow, had excellent correlation with myocardial distribution of 85Sr microspheres (r = 0.96, 0.93)] and 201Tl (r = 0.91 and 0.83), and enabled us to detect perfusion defects by in vivo scintigraphy. The agent, however, failed to have a useful degree of cardiac uptake in humans.
M L Thakur, and
C H Park, and
F Fazio, and
P Gerundini, and
A Margonato, and
G Vicedomini, and
R Colombo, and
F Colombo, and
M Gilardi, and
F Fregoso
January 2009,
Nuclear medicine and biology,
M L Thakur, and
C H Park, and
F Fazio, and
P Gerundini, and
A Margonato, and
G Vicedomini, and
R Colombo, and
F Colombo, and
M Gilardi, and
F Fregoso
April 2007,
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
M L Thakur, and
C H Park, and
F Fazio, and
P Gerundini, and
A Margonato, and
G Vicedomini, and
R Colombo, and
F Colombo, and
M Gilardi, and
F Fregoso
June 2000,
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao,
M L Thakur, and
C H Park, and
F Fazio, and
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G Vicedomini, and
R Colombo, and
F Colombo, and
M Gilardi, and
F Fregoso
January 2018,
Pakistan journal of pharmaceutical sciences,
M L Thakur, and
C H Park, and
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A Margonato, and
G Vicedomini, and
R Colombo, and
F Colombo, and
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F Fregoso
March 2006,
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
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F Fazio, and
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A Margonato, and
G Vicedomini, and
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F Colombo, and
M Gilardi, and
F Fregoso
January 2012,
Current radiopharmaceuticals,
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November 1973,
Radiology,
M L Thakur, and
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F Fregoso
March 1986,
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao,
M L Thakur, and
C H Park, and
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G Vicedomini, and
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F Colombo, and
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June 2024,
Molecular pharmaceutics,
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