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Changes in coronary haemodynamics and angina threshold were determined during atrial pacing in 11 patients with fixed obstructive coronary artery disease with effort angina before and after the administration of 20 mg of oral nifedipine. Coronary vascular resistance decreased at resting and at "subangina" heart rates but not at "angina" rates. Primary coronary vasodilatation with nifedipine was also suggested by higher coronary sinus oxygen content whether at rest or at subangina or angina heart rates. After nifedipine angina occurred at a lower double product and lower myocardial oxygen consumption. These findings suggest that nifedipine is a coronary vasodilator, but angina can occur at a lower angina threshold in some patients with obstructive coronary artery disease.
P H Kramer, and
K Chatterjee, and
A Schwartz, and
K Swedberg, and
J L Rouleau, and
D Curran, and
L Blevins, and
W W Parmley
October 1985,
Giornale italiano di cardiologia,
P H Kramer, and
K Chatterjee, and
A Schwartz, and
K Swedberg, and
J L Rouleau, and
D Curran, and
L Blevins, and
W W Parmley
January 1978,
Bollettino della Societa italiana di cardiologia,
P H Kramer, and
K Chatterjee, and
A Schwartz, and
K Swedberg, and
J L Rouleau, and
D Curran, and
L Blevins, and
W W Parmley
January 1983,
Catheterization and cardiovascular diagnosis,
P H Kramer, and
K Chatterjee, and
A Schwartz, and
K Swedberg, and
J L Rouleau, and
D Curran, and
L Blevins, and
W W Parmley
January 1981,
Circulation,
P H Kramer, and
K Chatterjee, and
A Schwartz, and
K Swedberg, and
J L Rouleau, and
D Curran, and
L Blevins, and
W W Parmley
January 1984,
Journal of cardiovascular pharmacology,
P H Kramer, and
K Chatterjee, and
A Schwartz, and
K Swedberg, and
J L Rouleau, and
D Curran, and
L Blevins, and
W W Parmley
December 1980,
European heart journal,
P H Kramer, and
K Chatterjee, and
A Schwartz, and
K Swedberg, and
J L Rouleau, and
D Curran, and
L Blevins, and
W W Parmley
February 1983,
Scandinavian journal of clinical and laboratory investigation,
P H Kramer, and
K Chatterjee, and
A Schwartz, and
K Swedberg, and
J L Rouleau, and
D Curran, and
L Blevins, and
W W Parmley
January 1980,
Bollettino della Societa italiana di cardiologia,
P H Kramer, and
K Chatterjee, and
A Schwartz, and
K Swedberg, and
J L Rouleau, and
D Curran, and
L Blevins, and
W W Parmley
January 1979,
Basic research in cardiology,
P H Kramer, and
K Chatterjee, and
A Schwartz, and
K Swedberg, and
J L Rouleau, and
D Curran, and
L Blevins, and
W W Parmley
July 1983,
The Journal of the Association of Physicians of India,
