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The Leukemia Intergroup Study has treated 110 patients with acute nonlymphocytic leukaemia with 'high dose' cytosine arabinoside remission induction therapy and studied the factors which were related to the outcome of therapy. With respect to death during remission induction therapy, only patient age was of prognostic significance. Treatment failure due to resistant leukaemia was associated with a high pretherapy leukaemic cell mass, the presence of few cells in S phase, and insensitivity of DNA synthesis to cytosine arabinoside. If, after 6 d of therapy, more than 40% of the marrow cells were leukaemic, the patient almost invariably failed to enter complete remission because of persistent leukaemia. Simultaneous consideration of the pretherapy labelling index and the per cent abnormal cells in the day 6 marrow permitted a distinction to be made between almost all patients who would enter remission or fail therapy because of persistent leukaemia.
H D Preisler, and
J Epstein, and
M Barcos, and
R Priore, and
A Raza, and
G P Browman, and
R Vogler, and
E Winton, and
H Grunwald, and
K Rai
April 1985,
British journal of haematology,
H D Preisler, and
J Epstein, and
M Barcos, and
R Priore, and
A Raza, and
G P Browman, and
R Vogler, and
E Winton, and
H Grunwald, and
K Rai
January 1984,
American journal of hematology,
H D Preisler, and
J Epstein, and
M Barcos, and
R Priore, and
A Raza, and
G P Browman, and
R Vogler, and
E Winton, and
H Grunwald, and
K Rai
January 1984,
Cancer chemotherapy and pharmacology,
H D Preisler, and
J Epstein, and
M Barcos, and
R Priore, and
A Raza, and
G P Browman, and
R Vogler, and
E Winton, and
H Grunwald, and
K Rai
August 1972,
Cancer chemotherapy reports,
H D Preisler, and
J Epstein, and
M Barcos, and
R Priore, and
A Raza, and
G P Browman, and
R Vogler, and
E Winton, and
H Grunwald, and
K Rai
July 1982,
British journal of haematology,
H D Preisler, and
J Epstein, and
M Barcos, and
R Priore, and
A Raza, and
G P Browman, and
R Vogler, and
E Winton, and
H Grunwald, and
K Rai
June 1987,
Seminars in oncology,
H D Preisler, and
J Epstein, and
M Barcos, and
R Priore, and
A Raza, and
G P Browman, and
R Vogler, and
E Winton, and
H Grunwald, and
K Rai
January 1983,
Blood,
H D Preisler, and
J Epstein, and
M Barcos, and
R Priore, and
A Raza, and
G P Browman, and
R Vogler, and
E Winton, and
H Grunwald, and
K Rai
January 1982,
Medical and pediatric oncology,
H D Preisler, and
J Epstein, and
M Barcos, and
R Priore, and
A Raza, and
G P Browman, and
R Vogler, and
E Winton, and
H Grunwald, and
K Rai
June 1984,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
H D Preisler, and
J Epstein, and
M Barcos, and
R Priore, and
A Raza, and
G P Browman, and
R Vogler, and
E Winton, and
H Grunwald, and
K Rai
January 1989,
Medical and pediatric oncology,
