Biomaterial Database

The effect of radiation alone and of radiation followed by hyperthermia on the vasculature of mouse intestine. 1984

P Falk

The effect on the vasculature of mouse intestine was observed following: (a) irradiation alone; and (b) irradiation followed at intervals of 0-60 days by hyperthermia. Specimens of intestine were removed after sacrifice and the vasculature revealed by benzidine staining before clearing in resin. The mean visible venous tree (VVT) was used as a parameter for assessing damage. The same hyperthermal treatment was used throughout: 1 h at 41.0 degrees C with the gut externalised. Following irradiation by 9 Gy, the VVT was not significantly reduced in the first 15 days, but decreased steadily by 34% in the next 45 days. In addition two transient reversible reductions occurred: the first immediately following irradiation, not counteracted by hyperthermia and thought to result from spasm; the second after about 40 days, counteracted by heating and thought to be caused by partial occlusion of the arterioles, resulting from irradiation. Reduction in VVT 26 days after irradiation appeared to be independent of dose from 6 to 10 Gy. Sensitivity to hyperthermia was maximal 15 days after irradiation.

UI	MeSH Term	Description	Entries
D007422	Intestines	The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.	Intestine
D008815	Mice, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.	Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D004307	Dose-Response Relationship, Radiation	The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.	Dose Response Relationship, Radiation,Dose-Response Relationships, Radiation,Radiation Dose-Response Relationship,Radiation Dose-Response Relationships,Relationship, Radiation Dose-Response,Relationships, Radiation Dose-Response
D005260	Female		Females
D006358	Hot Temperature	Presence of warmth or heat or a temperature notably higher than an accustomed norm.	Heat,Hot Temperatures,Temperature, Hot,Temperatures, Hot
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001158	Arteries	The vessels carrying blood away from the heart.	Artery
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D014680	Veins	The vessels carrying blood away from the CAPILLARY BEDS.	Vein
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus