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Eight subjects induced bronchospasm by free-range running. Four of these demonstrated a late response at 5-6 hr after exercise. When compared to the other group of four subjects, who also developed an early response but no late response, the difference in FEV1 at 5-6 hr was highly statistically significant. Although the phenomenon is not universally manifest it should no longer be held that there is no late response in exercise-induced asthma.
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