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Chromosome replication in mammalian cells in an ordered phenomenon. This is true also for the condensation in G2 of the heterochromatic chromosomal regions in mouse cells. The generality of this phenomenon and its mechanism are not known, nor is it known whether the order of condensation of the heterochromatic chromosomal segments in G2 reflects the order of replication or is independent of it. We determined the order of replication during the S phase and of condensation in G2 of the short heterochromatic chromosomal regions in the rat kangaroo cell line PtK2. The kinetics of condensation of these regions in G2 was studied in cells treated with Hoechst 33258. Their order of replication was established with the use of a sensitive technique based on the treatment of living cells with 5-bromodeoxyuridine and Hoechst 33258. Our results show that these regions exhibit a similar pattern of replication in S and condensation in G2.
R Goitein, and
J Hirschberg, and
M Marcus, and
K Sperling
March 1976,
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R Goitein, and
J Hirschberg, and
M Marcus, and
K Sperling
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R Goitein, and
J Hirschberg, and
M Marcus, and
K Sperling
February 1973,
Mutation research,
R Goitein, and
J Hirschberg, and
M Marcus, and
K Sperling
March 1973,
Science (New York, N.Y.),
R Goitein, and
J Hirschberg, and
M Marcus, and
K Sperling
August 1978,
Cytobiologie,
R Goitein, and
J Hirschberg, and
M Marcus, and
K Sperling
August 1976,
Journal of cell science,
R Goitein, and
J Hirschberg, and
M Marcus, and
K Sperling
August 1971,
Experimental cell research,
R Goitein, and
J Hirschberg, and
M Marcus, and
K Sperling
July 1976,
Journal of morphology,
R Goitein, and
J Hirschberg, and
M Marcus, and
K Sperling
January 1972,
Chromosoma,
R Goitein, and
J Hirschberg, and
M Marcus, and
K Sperling
February 1977,
The Journal of cell biology,
