-transparent.png){kind=logo}
We have used high resolution two-dimensional polyacrylamide gel electrophoresis (PAGE) to compare the polypeptides synthesized by normal human diploid fibroblasts cells which have significant proliferative capacity with those of cells which are terminally non-dividing. Normal cells that are terminally non-dividing (i.e., have no remaining proliferative potential) synthesize two polypeptides that are not detected in young cells which are either actively proliferating or growth arrested by incubation in medium containing a low concentration of serum (0.3%) for 72 h. Continued maintenance of young cells in the growth-arrested state ultimately leads to the detectable synthesis of one of the polypeptides synthesized by terminally non-dividing cells. Some preliminary biochemical properties of these two polypeptides are examined.
D W Lincoln, and
K I Braunschweiger, and
W R Braunschweiger, and
J R Smith
August 2018,
Science (New York, N.Y.),
D W Lincoln, and
K I Braunschweiger, and
W R Braunschweiger, and
J R Smith
January 1975,
Experimental cell research,
D W Lincoln, and
K I Braunschweiger, and
W R Braunschweiger, and
J R Smith
May 1985,
Cell biology international reports,
D W Lincoln, and
K I Braunschweiger, and
W R Braunschweiger, and
J R Smith
August 2013,
DNA repair,
D W Lincoln, and
K I Braunschweiger, and
W R Braunschweiger, and
J R Smith
June 1971,
Biochimica et biophysica acta,
D W Lincoln, and
K I Braunschweiger, and
W R Braunschweiger, and
J R Smith
July 1982,
The Journal of cell biology,
D W Lincoln, and
K I Braunschweiger, and
W R Braunschweiger, and
J R Smith
April 1965,
Revue des corps de sante des armees terre, mer, air,
D W Lincoln, and
K I Braunschweiger, and
W R Braunschweiger, and
J R Smith
July 2016,
Protoplasma,
D W Lincoln, and
K I Braunschweiger, and
W R Braunschweiger, and
J R Smith
August 1971,
FEBS letters,
D W Lincoln, and
K I Braunschweiger, and
W R Braunschweiger, and
J R Smith
January 1994,
Journal of andrology,
