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Despite a considerable amount of investigation, controversy continues concerning the use of indomethacin in inducing the closure of patent ductus arteriosus. This controversy may be attributable to differences in dosage, route of administration, postnatal age at treatment and the variable pharmacokinetics of the drug in premature infants. The pharmacokinetics and clinical efficacy of i.v. administered indomethacin in five premature infants with PDA were evaluated. There was considerable intersubject variability in the half life of elimination (63.1 +/- 38 h). This variability was mainly due to clearance (0.0086 +/- 0.0069 l/h/kg) rather than to distribution volume variability (0.54 +/- 0.27 l/kg). A reduction of half life was observed after the second dose, probably due to a maturation process. A permanent closure of the ductus was obtained in two patients after the first dose and in two patients after the second dose. The side-effects observed in our infants were transient and no long-term complication was attributable to this drug.
M B Regazzi, and
R Rondanelli, and
E Vidale, and
G Chirico, and
G Rondini, and
A Chiara, and
A Piccolo
January 1982,
Paediatrica Indonesiana,
M B Regazzi, and
R Rondanelli, and
E Vidale, and
G Chirico, and
G Rondini, and
A Chiara, and
A Piccolo
September 2008,
Pediatric cardiology,
M B Regazzi, and
R Rondanelli, and
E Vidale, and
G Chirico, and
G Rondini, and
A Chiara, and
A Piccolo
January 1986,
Developmental pharmacology and therapeutics,
M B Regazzi, and
R Rondanelli, and
E Vidale, and
G Chirico, and
G Rondini, and
A Chiara, and
A Piccolo
July 1980,
European journal of clinical pharmacology,
M B Regazzi, and
R Rondanelli, and
E Vidale, and
G Chirico, and
G Rondini, and
A Chiara, and
A Piccolo
June 1987,
Presse medicale (Paris, France : 1983),
M B Regazzi, and
R Rondanelli, and
E Vidale, and
G Chirico, and
G Rondini, and
A Chiara, and
A Piccolo
April 1987,
Lancet (London, England),
M B Regazzi, and
R Rondanelli, and
E Vidale, and
G Chirico, and
G Rondini, and
A Chiara, and
A Piccolo
October 1979,
The Journal of pediatrics,
M B Regazzi, and
R Rondanelli, and
E Vidale, and
G Chirico, and
G Rondini, and
A Chiara, and
A Piccolo
September 1988,
BMJ (Clinical research ed.),
M B Regazzi, and
R Rondanelli, and
E Vidale, and
G Chirico, and
G Rondini, and
A Chiara, and
A Piccolo
August 2009,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
M B Regazzi, and
R Rondanelli, and
E Vidale, and
G Chirico, and
G Rondini, and
A Chiara, and
A Piccolo
July 1963,
The Medical journal of Australia,
