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Leukotriene D4 and synthetic platelet-activating factor have been shown to qualitatively reproduce an antigen-induced airway response in rhesus monkeys at concentrations several hundred times less than histamine. In normal rhesus monkeys, challenges with concentrations of leukotriene D4 or platelet-activating factor, established as subthreshold doses (not producing a response), result in abnormal pulmonary function parameters when followed by a second challenge of a subthreshold dose. Results were similar with any sequence of leukotriene D4 and platelet-activating factor combination. This was not a result of additive effects of agonists, because previous experiments have shown that log or 0.5 log increases over the subthreshold dose are necessary for a response. Our results may suggest that these mediators that possess remarkable biologic activity might sensitize the lower airway for response to stimulation with the same or other mediators.
R Patterson, and
P R Bernstein, and
K E Harris, and
R D Krell
April 1990,
The American review of respiratory disease,
R Patterson, and
P R Bernstein, and
K E Harris, and
R D Krell
November 1987,
The Journal of laboratory and clinical medicine,
R Patterson, and
P R Bernstein, and
K E Harris, and
R D Krell
October 1987,
The American review of respiratory disease,
R Patterson, and
P R Bernstein, and
K E Harris, and
R D Krell
January 1988,
International archives of allergy and applied immunology,
R Patterson, and
P R Bernstein, and
K E Harris, and
R D Krell
December 1983,
The Journal of laboratory and clinical medicine,
R Patterson, and
P R Bernstein, and
K E Harris, and
R D Krell
November 1991,
European journal of pharmacology,
R Patterson, and
P R Bernstein, and
K E Harris, and
R D Krell
February 1994,
Pulmonary pharmacology,
R Patterson, and
P R Bernstein, and
K E Harris, and
R D Krell
May 1995,
Chemical & pharmaceutical bulletin,
R Patterson, and
P R Bernstein, and
K E Harris, and
R D Krell
August 1992,
The Journal of pharmacology and experimental therapeutics,
R Patterson, and
P R Bernstein, and
K E Harris, and
R D Krell
October 1990,
Arzneimittel-Forschung,
