BIOMAT Database Logo BIOMAT Database Logo

Dominant lethal mutations induced in mouse spermatogonia by antineoplastic drugs. 1984

L S Goldstein

Male mice were treated with nitrogen mustard (2.25 mg/kg), procarbazine (100 mg/kg) or vincristine (0.67 mg/kg). 5 weeks later they were mated to untreated females and the dominant lethal mutant rate was determined in the offspring by an in vitro analysis. Nitrogen mustard and procarbazine induced dominant lethal mutations to significant levels. Mutations were expressed, throughout early development, especially as a failure to form a trophectoderm outgrowth and to differentiate and proliferate an inner cell mass. Variations in the dominant lethal mutant rate were found from one week to the next, suggesting that differentiated and stem cell spermatogonia have differential sensitivity to mutation induction and cell killing by each drug.

UI MeSH Term Description Entries
D008297 Male Males
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D009588 Nitrogen Mustard Compounds A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens. Compounds, Nitrogen Mustard,Mustard Compounds, Nitrogen
D011344 Procarbazine An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. Matulane,Natulan,Procarbazine Hydrochloride,Procarbazine Monohydrobromide,Procarbazine Monohydrochloride,Hydrochloride, Procarbazine,Monohydrobromide, Procarbazine,Monohydrochloride, Procarbazine
D005799 Genes, Dominant Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state. Conditions, Dominant Genetic,Dominant Genetic Conditions,Genetic Conditions, Dominant,Condition, Dominant Genetic,Dominant Gene,Dominant Genes,Dominant Genetic Condition,Gene, Dominant,Genetic Condition, Dominant
D005804 Genes, Lethal Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability. Alleles, Lethal,Allele, Lethal,Gene, Lethal,Lethal Allele,Lethal Alleles,Lethal Gene,Lethal Genes
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000970 Antineoplastic Agents Substances that inhibit or prevent the proliferation of NEOPLASMS. Anticancer Agent,Antineoplastic,Antineoplastic Agent,Antineoplastic Drug,Antitumor Agent,Antitumor Drug,Cancer Chemotherapy Agent,Cancer Chemotherapy Drug,Anticancer Agents,Antineoplastic Drugs,Antineoplastics,Antitumor Agents,Antitumor Drugs,Cancer Chemotherapy Agents,Cancer Chemotherapy Drugs,Chemotherapeutic Anticancer Agents,Chemotherapeutic Anticancer Drug,Agent, Anticancer,Agent, Antineoplastic,Agent, Antitumor,Agent, Cancer Chemotherapy,Agents, Anticancer,Agents, Antineoplastic,Agents, Antitumor,Agents, Cancer Chemotherapy,Agents, Chemotherapeutic Anticancer,Chemotherapy Agent, Cancer,Chemotherapy Agents, Cancer,Chemotherapy Drug, Cancer,Chemotherapy Drugs, Cancer,Drug, Antineoplastic,Drug, Antitumor,Drug, Cancer Chemotherapy,Drug, Chemotherapeutic Anticancer,Drugs, Antineoplastic,Drugs, Antitumor,Drugs, Cancer Chemotherapy
D013093 Spermatogonia Euploid male germ cells of an early stage of SPERMATOGENESIS, derived from prespermatogonia. With the onset of puberty, spermatogonia at the basement membrane of the seminiferous tubule proliferate by mitotic then meiotic divisions and give rise to the haploid SPERMATOCYTES. Spermatophores,Spermatogonias,Spermatophore
D013094 Spermatozoa Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility. Sperm,Spermatozoon,X-Bearing Sperm,X-Chromosome-Bearing Sperm,Y-Bearing Sperm,Y-Chromosome-Bearing Sperm,Sperm, X-Bearing,Sperm, X-Chromosome-Bearing,Sperm, Y-Bearing,Sperm, Y-Chromosome-Bearing,Sperms, X-Bearing,Sperms, X-Chromosome-Bearing,Sperms, Y-Bearing,Sperms, Y-Chromosome-Bearing,X Bearing Sperm,X Chromosome Bearing Sperm,X-Bearing Sperms,X-Chromosome-Bearing Sperms,Y Bearing Sperm,Y Chromosome Bearing Sperm,Y-Bearing Sperms,Y-Chromosome-Bearing Sperms

Related Publications

L S Goldstein
The induction by x-irradiation of dominant lethal mutations in spermatogonia of mice.
February 1965, Mutation research,
L S Goldstein
Dominant lethal mutations induced by 14C in mice.
January 1981, Experientia,
L S Goldstein
[Dominant lethal mutations after irradiation of spermatogonia in mice of different ages].
January 1982, Roczniki Panstwowego Zakladu Higieny,
L S Goldstein
DOMINANT LETHAL MUTATIONS INDUCED IN MALE MICE BY METHYL METHANESULPHONATE.
May 1964, Heredity,
L S Goldstein
[Demonstration of dominant lethal mutations in early mouse embryogenesis].
January 1981, Genetika,
L S Goldstein
Dominant lethal mutations induced in mice by orally administered ethyl methanesulfonate.
October 1974, Mutation research,
L S Goldstein
An in vitro technique to detect dominant lethal mutations induced in mouse oocytes by ethyl methanesulphonate exposure in vivo.
January 1990, Toxicology in vitro : an international journal published in association with BIBRA,
L S Goldstein
Investigation of hyperthermia-induced dominant lethal mutations in male mice.
January 1981, The Journal of heredity,
L S Goldstein
Radiation-induced dominant lethal mutations in oocytes of Musca domestica.
November 1979, Mutation research,
L S Goldstein
[Temperature-sensitive autosomal dominant lethal mutations in Drosophila melanogaster induced by ethylmethane sulfonate].
April 1983, Genetika,
Copied contents to your clipboard!