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The acute hemodynamic effects of both sublingual nifedipine (N) and intravenous hydralazine (Hy) were studied in 5 patients with primary pulmonary hypertension to ascertain whether the capacity for pulmonary vasodilatation was generalized or drug-specific, and to determine which of the 2 agents had preferential pulmonary vasodilatory effects. For the group as a whole, neither N nor Hy produced changes in heart rate, mean pulmonary capillary wedge or right atrial pressures. Both N and Hy reduced mean systemic arterial pressure (before N 90 +/- 8 mm Hg, after N 76 +/- 7 mm Hg, p less than 0.01; before Hy 92 +/- 11 mm Hg, after Hy 68 +/- 8 mm Hg, p less than 0.05), and decreased systemic vascular resistance (before N 1,558 +/- 645 dynes s cm-5, after N 1,192 +/- 430 dynes s cm-5, p less than 0.05; before Hy 1,700 +/- 415 dynes s cm-5, after Hy 957 +/- 285 dynes s cm-5, p less than 0.05). In addition, N administration resulted in an increased cardiac output (before N 4.5 +/- 2.0 liters/min, after N 4.8 +/- 2.0 liters/min, p less than 0.01); Hy administration was associated with a more varied effect on cardiac output (before Hy 4.0 +/- 1.0 liters/min, after Hy 5.3 +/- 1.8 liters/min, p less than 0.10, difference not significant [NS]).(ABSTRACT TRUNCATED AT 250 WORDS)
J Fisher, and
J S Borer, and
J W Moses, and
H L Goldberg, and
A P Niarchos, and
H H Whitman, and
M Mermelstein
July 1983,
Journal of the American College of Cardiology,
J Fisher, and
J S Borer, and
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H L Goldberg, and
A P Niarchos, and
H H Whitman, and
M Mermelstein
January 1982,
Giornale italiano di cardiologia,
J Fisher, and
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H L Goldberg, and
A P Niarchos, and
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M Mermelstein
January 1983,
Journal of clinical pharmacology,
J Fisher, and
J S Borer, and
J W Moses, and
H L Goldberg, and
A P Niarchos, and
H H Whitman, and
M Mermelstein
November 1983,
The American journal of cardiology,
J Fisher, and
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M Mermelstein
February 1986,
Kokyu to junkan. Respiration & circulation,
J Fisher, and
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H L Goldberg, and
A P Niarchos, and
H H Whitman, and
M Mermelstein
July 1984,
Chest,
J Fisher, and
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A P Niarchos, and
H H Whitman, and
M Mermelstein
September 1980,
British heart journal,
J Fisher, and
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J W Moses, and
H L Goldberg, and
A P Niarchos, and
H H Whitman, and
M Mermelstein
August 1981,
British heart journal,
J Fisher, and
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H L Goldberg, and
A P Niarchos, and
H H Whitman, and
M Mermelstein
December 1985,
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J Fisher, and
J S Borer, and
J W Moses, and
H L Goldberg, and
A P Niarchos, and
H H Whitman, and
M Mermelstein
January 1985,
Acta cardiologica,
