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General and specific immune function were examined in women with endometriosis. Nonspecific parameters included total leukocyte and differential counts, quantitative immunoglobulin (IgG, IgA, and IgM) determinations, total hemolytic complement, C3, C4, mitogen-induced lymphocyte stimulation, and human leukocyte antigen (HLA) typing; no differences were observed when data were compared to age-matched controls without endometriosis. In contrast, the specific immune response T-lymphocyte-mediated cytotoxicity to autologous endometrial cells was significantly reduced (P less than 0.01) in women with endometriosis. When results from patients were analyzed according to clinical severity of endometriosis, even more striking immunologic alterations were delineated. In addition, lymphocyte stimulation responses to autologous endometrial antigen were lower in patients with severe or moderate disease, approaching statistical significance (P = 0.18 and 0.12, respectively). These studies suggest an immunologic basis for development of endometriosis.
R W Steele, and
W P Dmowski, and
D J Marmer
January 1992,
Zentralblatt fur Gynakologie,
R W Steele, and
W P Dmowski, and
D J Marmer
March 1989,
Obstetrics and gynecology clinics of North America,
R W Steele, and
W P Dmowski, and
D J Marmer
February 1989,
Ginekologia polska,
R W Steele, and
W P Dmowski, and
D J Marmer
January 1992,
Journal de gynecologie, obstetrique et biologie de la reproduction,
R W Steele, and
W P Dmowski, and
D J Marmer
January 1987,
Contributions to gynecology and obstetrics,
R W Steele, and
W P Dmowski, and
D J Marmer
June 1981,
Ceskoslovenska gynekologie,
R W Steele, and
W P Dmowski, and
D J Marmer
January 1990,
Progress in clinical and biological research,
R W Steele, and
W P Dmowski, and
D J Marmer
February 1992,
Akusherstvo i ginekologiia,
R W Steele, and
W P Dmowski, and
D J Marmer
January 2002,
Ginekologia polska,
R W Steele, and
W P Dmowski, and
D J Marmer
January 1961,
Fertility and sterility,
