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The effect on heart rate of different rates of injection (10 seconds, 1, 3 and 5 minutes) of a fixed dose (neostigmine 2.5 mg and atropine 1.2 mg) and a weight-related dose (neostigmine 50 micrograms/kg and atropine 25 micrograms/kg) of neostigmine-atropine mixture given for the reversal of residual competitive neuromuscular block was studied in 196 healthy adult patients. In both series slow injection lessened and delayed the initial rise in heart rate. The subsequent fall in heart rate was less when the drugs were injected over 3 min compared with the 10 seconds and 1 minute injection groups but when given over 5 minutes there was a steady fall in heart rate, more so with the weight-related dose. It is recommended that a neostigmine and atropine mixture should be administered over 3 min.
K W Harper, and
I M Bali, and
F M Gibson, and
R Carlisle, and
I H Black, and
D J Grainger, and
J W Dundee
November 1984,
Canadian Anaesthetists' Society journal,
K W Harper, and
I M Bali, and
F M Gibson, and
R Carlisle, and
I H Black, and
D J Grainger, and
J W Dundee
January 1977,
Anesthesia and analgesia,
K W Harper, and
I M Bali, and
F M Gibson, and
R Carlisle, and
I H Black, and
D J Grainger, and
J W Dundee
November 1994,
British journal of anaesthesia,
K W Harper, and
I M Bali, and
F M Gibson, and
R Carlisle, and
I H Black, and
D J Grainger, and
J W Dundee
April 1993,
Anesthesiology,
K W Harper, and
I M Bali, and
F M Gibson, and
R Carlisle, and
I H Black, and
D J Grainger, and
J W Dundee
August 1977,
British journal of anaesthesia,
K W Harper, and
I M Bali, and
F M Gibson, and
R Carlisle, and
I H Black, and
D J Grainger, and
J W Dundee
June 1986,
Journal of the Royal Society of Medicine,
K W Harper, and
I M Bali, and
F M Gibson, and
R Carlisle, and
I H Black, and
D J Grainger, and
J W Dundee
February 1980,
Middle East journal of anaesthesiology,
K W Harper, and
I M Bali, and
F M Gibson, and
R Carlisle, and
I H Black, and
D J Grainger, and
J W Dundee
February 2001,
Middle East journal of anaesthesiology,
K W Harper, and
I M Bali, and
F M Gibson, and
R Carlisle, and
I H Black, and
D J Grainger, and
J W Dundee
June 2016,
Middle East journal of anaesthesiology,
K W Harper, and
I M Bali, and
F M Gibson, and
R Carlisle, and
I H Black, and
D J Grainger, and
J W Dundee
January 1990,
Research in veterinary science,
