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Tritium labelled heterogeneous nuclear RNA (HnRNA) from normal and chronic lymphocytic leukemic (CLL) lymphocytes was investigated before and after fractionation into non-poly(A) containing (-HnRNA) and poly(A) containing (+HnRNA) HnRNA with respect to double stranded RNA (dsRNA). Statistically significant higher amounts of rapidly labelled RNA were recovered from CLL lymphocytes when compared to normal cases. Within the CLL cases a significant linear correlation (r = 0.95) was found between white blood cell counts and the amount of dsRNA in total HnRNA. After fractionation into (-) and (+) HnRNAs the ratios of dsRNAs, expressed as the dsRNA in (-) HnRNA divided by the dsRNA in (+) HnRNA, was lower than the corresponding values in normal cases for all the CLL cases except one. The relationship between (+) HnRNA and the total dsRNA level was different when comparing CLL and normal lymphocytes indicating a RNA processing abnormality.
P E Månsson, and
R W Pero, and
L Brandt
March 1975,
Scandinavian journal of haematology,
P E Månsson, and
R W Pero, and
L Brandt
October 1976,
Scandinavian journal of haematology,
P E Månsson, and
R W Pero, and
L Brandt
September 1972,
Proceedings of the National Academy of Sciences of the United States of America,
P E Månsson, and
R W Pero, and
L Brandt
January 1979,
International review of cytology,
P E Månsson, and
R W Pero, and
L Brandt
January 1972,
Journal of immunology (Baltimore, Md. : 1950),
P E Månsson, and
R W Pero, and
L Brandt
November 1979,
Blood,
P E Månsson, and
R W Pero, and
L Brandt
September 1977,
Proceedings of the National Academy of Sciences of the United States of America,
P E Månsson, and
R W Pero, and
L Brandt
January 1974,
Archivum immunologiae et therapiae experimentalis,
P E Månsson, and
R W Pero, and
L Brandt
July 1997,
The Journal of cell biology,
P E Månsson, and
R W Pero, and
L Brandt
January 1975,
The Journal of clinical investigation,
