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Lambs were inoculated IV with 3.2 X 10(3) colony forming units (CFU) to 3.2 X 10(6) CFU of Corynebacterium pseudotuberculosis from a 6-hour broth culture supplemented with 0.1% sorbitan monooleate. After 28 days, multiple abscesses were observed in the lungs and lymph nodes. The number of abscesses in the lungs correlated with the inoculation dose. Two lambs given 10(5) CFU and 10(6) CFU died. Multiple abscesses occurred in other lambs given 10(6) CFU to 10(4) CFU and few abscesses occurred in lambs given 10(3) CFU. Corynebacterium pseudotuberculosis was isolated from lung abscesses, inoculation site abscesses, and lymph node abscesses, but not from normal tissues. Because this procedure consistently induced abscesses in the lungs, we believe it will be a suitable challenge system for studies on the prevention of caseous lymphadenitis in sheep.
K A Brogden, and
R C Cutlip, and
H D Lehmkuhl
October 1991,
Veterinary microbiology,
K A Brogden, and
R C Cutlip, and
H D Lehmkuhl
February 1991,
Veterinary microbiology,
K A Brogden, and
R C Cutlip, and
H D Lehmkuhl
May 1953,
Journal of the American Veterinary Medical Association,
K A Brogden, and
R C Cutlip, and
H D Lehmkuhl
February 1997,
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases,
K A Brogden, and
R C Cutlip, and
H D Lehmkuhl
January 1989,
Acta veterinaria Scandinavica,
K A Brogden, and
R C Cutlip, and
H D Lehmkuhl
December 2003,
The Veterinary record,
K A Brogden, and
R C Cutlip, and
H D Lehmkuhl
October 2003,
Epidemiology and infection,
K A Brogden, and
R C Cutlip, and
H D Lehmkuhl
December 2004,
Journal of the American Veterinary Medical Association,
K A Brogden, and
R C Cutlip, and
H D Lehmkuhl
May 1992,
Research in veterinary science,
K A Brogden, and
R C Cutlip, and
H D Lehmkuhl
December 1969,
The Onderstepoort journal of veterinary research,
