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The effects of dopamine infusion (10 and 20 micrograms kg-1 min-1) on pulmonary arterial pressure (PAP) and pulmonary arterial resistance (PAR) were studied. Experiments were carried out on 60 anesthetized dogs using two different models: model A, with mechanical perfusion of pulmonary circulation and constant left ventricular output, and model B, with physiologic pulmonary perfusion and non-fixed ventricular output. When pulmonary blood flow was constant, dopamine did not change PAP or PAR at either dose. When cardiac output (CO) was allowed to increase, PAP increased with dopamine at both doses, whereas PAR did not change with 20 micrograms kg-1 min-1 dopamine and was reduced by the 10 micrograms kg-1 min-1 dose. We conclude that the increase in PAP could not be explained solely by the rise in CO, but was probably related to an inhibitory effect of dopamine on pulmonary vascular accommodation and to increases in CO, especially when the drug was utilized at higher doses.
M A Moraes-Silva, and
R R Andrade, and
R A Oliveira, and
J Spadaro, and
P R Curi, and
W S Hossne
September 1952,
The American journal of physiology,
M A Moraes-Silva, and
R R Andrade, and
R A Oliveira, and
J Spadaro, and
P R Curi, and
W S Hossne
June 1976,
The Journal of thoracic and cardiovascular surgery,
M A Moraes-Silva, and
R R Andrade, and
R A Oliveira, and
J Spadaro, and
P R Curi, and
W S Hossne
March 1977,
Pflugers Archiv : European journal of physiology,
M A Moraes-Silva, and
R R Andrade, and
R A Oliveira, and
J Spadaro, and
P R Curi, and
W S Hossne
September 1974,
European journal of pharmacology,
M A Moraes-Silva, and
R R Andrade, and
R A Oliveira, and
J Spadaro, and
P R Curi, and
W S Hossne
April 1995,
The Journal of veterinary medical science,
M A Moraes-Silva, and
R R Andrade, and
R A Oliveira, and
J Spadaro, and
P R Curi, and
W S Hossne
July 1984,
Masui. The Japanese journal of anesthesiology,
M A Moraes-Silva, and
R R Andrade, and
R A Oliveira, and
J Spadaro, and
P R Curi, and
W S Hossne
September 1963,
The American journal of the medical sciences,
M A Moraes-Silva, and
R R Andrade, and
R A Oliveira, and
J Spadaro, and
P R Curi, and
W S Hossne
January 1970,
American heart journal,
M A Moraes-Silva, and
R R Andrade, and
R A Oliveira, and
J Spadaro, and
P R Curi, and
W S Hossne
January 1986,
Pediatric pharmacology (New York, N.Y.),
M A Moraes-Silva, and
R R Andrade, and
R A Oliveira, and
J Spadaro, and
P R Curi, and
W S Hossne
March 1976,
American heart journal,
