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1. A quantitative thin-layer chromatographic procedure for theophylline has been evaluated. An internal standard, 3-isobutyl-1-methylxanthine, a compound similar in properties to those of theophylline is added to the specimen prior to extraction to eliminate the need for accurate measurements of volume during extraction or analysis. 2. This method does not show interference from other xanthines and from a number of drugs commonly prescribed with thephylline. It has an acceptable correlation with a reference gas-liquid chromatographic procedure. 3. This procedure is capable of handling batches of six or more samples faster than the serial processing of either high performance liquid chromatography or gas-liquid chromatography.
R N Gupta, and
F Eng, and
M Stefanec
February 1975,
The Journal of pharmacy and pharmacology,
R N Gupta, and
F Eng, and
M Stefanec
January 2002,
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques,
R N Gupta, and
F Eng, and
M Stefanec
March 1978,
Annals of clinical biochemistry,
R N Gupta, and
F Eng, and
M Stefanec
June 1967,
Indian journal of biochemistry,
R N Gupta, and
F Eng, and
M Stefanec
October 1965,
The Journal of pharmacy and pharmacology,
R N Gupta, and
F Eng, and
M Stefanec
October 1970,
Journal of chromatography,
R N Gupta, and
F Eng, and
M Stefanec
February 1973,
Journal of chromatography,
R N Gupta, and
F Eng, and
M Stefanec
January 1995,
Methods in enzymology,
R N Gupta, and
F Eng, and
M Stefanec
October 1967,
The New Zealand medical journal,
R N Gupta, and
F Eng, and
M Stefanec
January 1976,
Clinica chimica acta; international journal of clinical chemistry,
