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1. Steady-state plasma levels of warfarin were measured in thirty-nine ambulatory patients attending a haematology clinic. 2. Plasma concentrations, plasma clearance, and prothrombin ratio showed no significant differences when patients below 65 years of age were compared with those above 65 years. The mean daily maintenance dose of warfarin required was marginally greater for the younger patients but the difference was not statistically significant (P = 0.10). 3. A significant relationship was found between the daily maintenance dose of warfarin required by all patients and their mean steady-state plasma level (r = 0.5667, P less than 0.001). 4. For one elderly hospitalized patient it was apparent that there was a marked depression of the vitamin K-dependent clotting factor synthesis by warfarin which was associated with a hypoprothrombinaemic response.
K Hotraphinyo, and
E J Triggs, and
B Maybloom, and
A Maclaine-Cross
November 1995,
Clinical pharmacology and therapeutics,
K Hotraphinyo, and
E J Triggs, and
B Maybloom, and
A Maclaine-Cross
November 1989,
Therapeutic drug monitoring,
K Hotraphinyo, and
E J Triggs, and
B Maybloom, and
A Maclaine-Cross
December 1981,
British journal of clinical pharmacology,
K Hotraphinyo, and
E J Triggs, and
B Maybloom, and
A Maclaine-Cross
January 1987,
Therapeutic drug monitoring,
K Hotraphinyo, and
E J Triggs, and
B Maybloom, and
A Maclaine-Cross
December 1980,
Clinical pharmacology and therapeutics,
K Hotraphinyo, and
E J Triggs, and
B Maybloom, and
A Maclaine-Cross
December 1982,
British journal of clinical pharmacology,
K Hotraphinyo, and
E J Triggs, and
B Maybloom, and
A Maclaine-Cross
February 1976,
Clinical pharmacology and therapeutics,
K Hotraphinyo, and
E J Triggs, and
B Maybloom, and
A Maclaine-Cross
September 1979,
British journal of clinical pharmacology,
K Hotraphinyo, and
E J Triggs, and
B Maybloom, and
A Maclaine-Cross
April 1982,
The American journal of psychiatry,
K Hotraphinyo, and
E J Triggs, and
B Maybloom, and
A Maclaine-Cross
December 1991,
Clinical pharmacy,
