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Ro 03-8799, a lipophilic nitroimidazole with a basic side chain, has now been administered intravenously to 69 patients. The elimination half-life in plasma was 5.1 hr and the plasma concentration at 30 min was 14.8 micrograms/ml standardized to a dose of 1 g per square meter of surface area. Immediate symptoms of malaise, heat, sweating and disorientation limit the amount of the drug which may be given on any one occasion. However, a dose of 750 mg per square meter of surface area may be given combined with daily radiotherapy. Our data suggest that when given with a 20 fraction course of radiotherapy, sensitization of hypoxic cells may be achieved equal to a 10-fold increase in the dose of misonidazole above that presently permitted.
M I Saunders, and
P J Anderson, and
M H Bennett, and
S Dische, and
A Minchinton, and
M R Stratford, and
M Tothill
January 1984,
European journal of clinical pharmacology,
M I Saunders, and
P J Anderson, and
M H Bennett, and
S Dische, and
A Minchinton, and
M R Stratford, and
M Tothill
May 1990,
International journal of radiation oncology, biology, physics,
M I Saunders, and
P J Anderson, and
M H Bennett, and
S Dische, and
A Minchinton, and
M R Stratford, and
M Tothill
September 1986,
The British journal of radiology,
M I Saunders, and
P J Anderson, and
M H Bennett, and
S Dische, and
A Minchinton, and
M R Stratford, and
M Tothill
May 1989,
British journal of cancer,
M I Saunders, and
P J Anderson, and
M H Bennett, and
S Dische, and
A Minchinton, and
M R Stratford, and
M Tothill
February 1986,
The British journal of radiology,
M I Saunders, and
P J Anderson, and
M H Bennett, and
S Dische, and
A Minchinton, and
M R Stratford, and
M Tothill
July 1986,
International journal of radiation oncology, biology, physics,
M I Saunders, and
P J Anderson, and
M H Bennett, and
S Dische, and
A Minchinton, and
M R Stratford, and
M Tothill
November 1988,
International journal of radiation oncology, biology, physics,
M I Saunders, and
P J Anderson, and
M H Bennett, and
S Dische, and
A Minchinton, and
M R Stratford, and
M Tothill
January 1991,
Cancer chemotherapy and pharmacology,
M I Saunders, and
P J Anderson, and
M H Bennett, and
S Dische, and
A Minchinton, and
M R Stratford, and
M Tothill
April 1989,
International journal of radiation oncology, biology, physics,
M I Saunders, and
P J Anderson, and
M H Bennett, and
S Dische, and
A Minchinton, and
M R Stratford, and
M Tothill
July 1986,
International journal of radiation oncology, biology, physics,
