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The presence and extent of focal-segmental glomerulosclerosis/hyalinosis (FSSH) was determined in 79 autopsy cases of analgesic nephropathy and correlated with the levels of proteinuria, serum creatinine and arterial blood pressure. FSSH was present in 77% of cases. The extent of FSSH correlates positively with increasing proteinuria and serum creatinine. The widely scattered pattern suggests a multifactorial pathogenesis for FSSH in analgesic nephropathy, including, for example, glomerular overload and arterial hypertension. Mesangial proliferative glomerulonephritis was observed in only two cases.
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