Biomaterial Database

Single dose and cross tolerance studies of beta-phenethylamine, d-amphetamine and LSD in the chronic spinal dog. 1978

D B Vaupel, and M Nozaki, and W R Martin, and L D Bright

The effects of beta-phenethylamine (PEA), d-amphetamine and LSD were studied on spinal reflexes, autonomic signs, and behavior in the non-tolerant and LSD tolerant (30 microgram/kg/day) chronic spinal dog. LSD (10 microgram/kg) facilitated the flexor reflex, produced the stepping reflex, increased respiration, pulse rate and temperature, slightly dilated pupils and produced whining, tracking and restlessness. Direct tolerance developed to all of these effects except temperature. PEA (0.8 mg/kg/min infused for 12 min) and amphetamine (3.2 mg/kg) facilitated the flexor reflex, increased respiration, temperature and the skin twitch reflex latency, caused a marked mydriasis, retracted the nictitating membrane and produced restlessness and stereotypic head movements. PEA but not amphetamine elicited stepping, and only amphetamine consistently slowed heart rate. No cross tolerance to the physiologic or behavioral effects of amphetamine was observed. Partial tolerance developed only to the actions of PEA on the stepping reflex and the nictitating membrane. The single dose effects and the lack of cross tolerance to amphetamine and PEA suggest modes of action different from LSD. PEA has some actions which differ from those of amphetamine.

UI	MeSH Term	Description	Entries
D008238	Lysergic Acid Diethylamide	Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood.	LSD,Lysergide,LSD-25,Lysergic Acid Diethylamide Tartrate,Acid Diethylamide, Lysergic,Diethylamide, Lysergic Acid,LSD 25
D010627	Phenethylamines	A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)	Phenylethylamines
D011674	Pulse	The rhythmical expansion and contraction of an ARTERY produced by waves of pressure caused by the ejection of BLOOD from the left ventricle of the HEART as it contracts.	Pulses
D011680	Pupil	The aperture in the iris through which light passes.	Pupils
D012018	Reflex	An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.
D012119	Respiration	The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (	Breathing
D001831	Body Temperature	The measure of the level of heat of a human or animal.	Organ Temperature,Body Temperatures,Organ Temperatures,Temperature, Body,Temperature, Organ,Temperatures, Body,Temperatures, Organ
D003714	Denervation	The resection or removal of the nerve to an organ or part.	Laser Neurectomy,Neurectomy,Peripheral Neurectomy,Radiofrequency Neurotomy,Denervations,Laser Neurectomies,Neurectomies,Neurectomies, Laser,Neurectomies, Peripheral,Neurectomy, Laser,Neurectomy, Peripheral,Neurotomies, Radiofrequency,Neurotomy, Radiofrequency,Peripheral Neurectomies,Radiofrequency Neurotomies
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D004351	Drug Resistance	Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.	Resistance, Drug