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Six healthy volunteers participated in a randomized, double-blind cross-over study of the effects of intravenous aminophylline on diazepam-induced sedation. Each subject participated in two phases and in each phase received either diazepam (15 mg intravenously) followed by placebo or diazepam followed by aminophylline (2 mg/kg intravenously). Critical flicker fusion times and reaction times were measured sequentially as indices of vigilance. Subjects also assessed their own vigilance on a visual analogue scale. Aminophylline given after diazepam significantly improved vigilance as measured by the visual analogue scale from 60 to 150 min after administration of diazepam, while total reaction time was significantly improved at 90, 210, and 270 min. There was no significant correlation between theophylline plasma levels and its effects on vigilance.
B H Meyer, and
O F Weis, and
F O Müller
June 1989,
Ma zui xue za zhi = Anaesthesiologica Sinica,
B H Meyer, and
O F Weis, and
F O Müller
January 1985,
Giornale di anestesia stomatologica = Journal of dental anaesthesia,
B H Meyer, and
O F Weis, and
F O Müller
December 1979,
Acta anaesthesiologica Belgica,
B H Meyer, and
O F Weis, and
F O Müller
April 1980,
British journal of anaesthesia,
B H Meyer, and
O F Weis, and
F O Müller
February 1989,
Acta anaesthesiologica Scandinavica,
B H Meyer, and
O F Weis, and
F O Müller
April 1980,
Anesthesiology,
B H Meyer, and
O F Weis, and
F O Müller
November 1987,
Revista medica de Chile,
B H Meyer, and
O F Weis, and
F O Müller
December 1982,
Lancet (London, England),
B H Meyer, and
O F Weis, and
F O Müller
July 1987,
Indian pediatrics,
B H Meyer, and
O F Weis, and
F O Müller
October 1986,
Acta anaesthesiologica Scandinavica,
