-transparent.png){kind=logo}
The effects of ethanol on both Ca2+ pump activity and Ca2+-induced Ca2+ release in sarcoplasmic reticulum (SR) of rabbit skeletal muscle were studied. In concentrations of 0.1-1.0%, ethanol conspicuously enhanced Ca2+ release from the heavy fraction of SR, whereas a much smaller effect was noted in the light fraction. When Ca2+-induced Ca2+ release was inhibited by 10 mM Mg2+, the Ca2+ pump activities of both the heavy and light SR were the same; the activities were not significantly influenced by 1% ethanol. Ethanol itself did not release Ca2+ from the heavy SR. However, it appeared to render the heavy SR more permeable to Ca2+, thereby decreasing the amount of storable Ca2+. This action of ethanol may be related to the mechanism of its negative inotropic effect.
S T Ohnishi, and
J L Flick, and
E Rubin
February 1988,
Biochimica et biophysica acta,
S T Ohnishi, and
J L Flick, and
E Rubin
April 1994,
European journal of biochemistry,
S T Ohnishi, and
J L Flick, and
E Rubin
January 1985,
Membrane biochemistry,
S T Ohnishi, and
J L Flick, and
E Rubin
October 1988,
FEBS letters,
S T Ohnishi, and
J L Flick, and
E Rubin
March 1983,
Proceedings of the National Academy of Sciences of the United States of America,
S T Ohnishi, and
J L Flick, and
E Rubin
March 1993,
Archives of biochemistry and biophysics,
S T Ohnishi, and
J L Flick, and
E Rubin
July 1971,
Biochemistry,
S T Ohnishi, and
J L Flick, and
E Rubin
August 1987,
Journal of biochemistry,
S T Ohnishi, and
J L Flick, and
E Rubin
January 1988,
Progress in clinical and biological research,
S T Ohnishi, and
J L Flick, and
E Rubin
February 1992,
Archives of biochemistry and biophysics,
