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The effect of vitamin A and of some of its derivatives on chondrocytes in culture has been studied. In the presence of retinoids the proliferation of the cells decreased and they lost their characteristic polygonal shape and assumed a fibroblast-like morphology. All retinoids also caused dedifferentiation of chondrocytes as indicated by the induction of types I and III collagen. 13-cis retinoic acid (= isotretinoin) was the most active derivative in this aspect. Since appropriate control of the synthesis of extracellular matrix proteins is a prerequisite for their normal physiological function, alterations such as those observed here may be involved in the pathogenesis of side effects which are observed during the treatment of dermatological disorders with retinoic acid derivatives.
R Hein, and
T Krieg, and
P K Mueller, and
O Braun-Falco
May 1982,
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R Hein, and
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P K Mueller, and
O Braun-Falco
August 1982,
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R Hein, and
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August 1977,
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R Hein, and
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January 2011,
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R Hein, and
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P K Mueller, and
O Braun-Falco
September 1981,
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R Hein, and
T Krieg, and
P K Mueller, and
O Braun-Falco
January 1982,
Experimental cell biology,
R Hein, and
T Krieg, and
P K Mueller, and
O Braun-Falco
February 1976,
Biochemical and biophysical research communications,
R Hein, and
T Krieg, and
P K Mueller, and
O Braun-Falco
April 1994,
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R Hein, and
T Krieg, and
P K Mueller, and
O Braun-Falco
February 1988,
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R Hein, and
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O Braun-Falco
March 1995,
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