-transparent.png){kind=logo}
The frequency of spontaneous instability of lymphocyte chromosomes of the first 2 mitoses, the rate of sister chromatid exchanges (SCEs), and the proliferative kinetics of lymphocytes were studied in a 6-year-old girl with Fanconi's anemia (FA) and in 4 healthy donors. The frequencies of aberrant cells and the total number of chromosome breaks in the FA patient decreased with cell transition from the first to the second mitosis. The FA lymphocytes had a slower proliferative kinetics and the level of SCEs was higher as compared with control. The probability of chromatid deletions at the sites of SCEs localization and in the dark and light stained chromatids was unequal. 33.8% of chromatid breaks were associated with SCEs. The data point to the relationship between SCEs and spontaneous chromosome instability in AF cells.
S A Nazarenko, and
Iu E Burmakina
October 1975,
Proceedings of the National Academy of Sciences of the United States of America,
S A Nazarenko, and
Iu E Burmakina
January 1975,
Humangenetik,
S A Nazarenko, and
Iu E Burmakina
February 1981,
Haematologica,
S A Nazarenko, and
Iu E Burmakina
September 1975,
Humangenetik,
S A Nazarenko, and
Iu E Burmakina
November 1977,
Human genetics,
S A Nazarenko, and
Iu E Burmakina
January 2000,
Hereditas,
S A Nazarenko, and
Iu E Burmakina
January 1977,
Cytogenetics and cell genetics,
S A Nazarenko, and
Iu E Burmakina
January 1982,
Human genetics,
S A Nazarenko, and
Iu E Burmakina
October 1976,
Experimental cell research,
S A Nazarenko, and
Iu E Burmakina
January 1977,
Cytogenetics and cell genetics,
