-transparent.png){kind=logo}
In man, unconjugated plasma DA is normally undetectable or present in minute amounts. Twelve medication-free volunteers received a 1 mg dose of dexamethasone which produced pronounced increases of plasma free DA but not of other catecholamines. Mean plasma free dopamine levels after dexamethasone at 8 a.m. (155 +/- 102 pg/ml) and 4 p.m. (163 +/- 70 pg/ml) were significantly higher (p less than 0.001) than those at 8 a.m. (50 +/- 18 pg/ml) and 4 p.m. (42 +/- 7 pg/ml) before dexamethasone. Although the mechanism of increased dopaminergic activity after a dose of dexamethasone remains for future research, the data presented in this paper may explain the observations that corticosteroids lower prolactin levels and may induce psychiatric disturbances, as well as the finding that depressed patients with high postdexamethasone cortisol levels are frequently psychotic.
A J Rothschild, and
P J Langlais, and
A F Schatzberg, and
F X Walsh, and
J O Cole, and
E D Bird
June 1995,
Hypertension research : official journal of the Japanese Society of Hypertension,
A J Rothschild, and
P J Langlais, and
A F Schatzberg, and
F X Walsh, and
J O Cole, and
E D Bird
August 1990,
Journal of neurology,
A J Rothschild, and
P J Langlais, and
A F Schatzberg, and
F X Walsh, and
J O Cole, and
E D Bird
January 1989,
Clinical and experimental hypertension. Part A, Theory and practice,
A J Rothschild, and
P J Langlais, and
A F Schatzberg, and
F X Walsh, and
J O Cole, and
E D Bird
December 1977,
The Journal of clinical endocrinology and metabolism,
A J Rothschild, and
P J Langlais, and
A F Schatzberg, and
F X Walsh, and
J O Cole, and
E D Bird
January 1992,
Archives of disease in childhood,
A J Rothschild, and
P J Langlais, and
A F Schatzberg, and
F X Walsh, and
J O Cole, and
E D Bird
June 1988,
Danish medical bulletin,
A J Rothschild, and
P J Langlais, and
A F Schatzberg, and
F X Walsh, and
J O Cole, and
E D Bird
August 1984,
Journal of endocrinological investigation,
A J Rothschild, and
P J Langlais, and
A F Schatzberg, and
F X Walsh, and
J O Cole, and
E D Bird
October 1985,
Psychiatry research,
A J Rothschild, and
P J Langlais, and
A F Schatzberg, and
F X Walsh, and
J O Cole, and
E D Bird
September 1990,
The American journal of the medical sciences,
A J Rothschild, and
P J Langlais, and
A F Schatzberg, and
F X Walsh, and
J O Cole, and
E D Bird
January 1981,
Hormone research,
