-transparent.png){kind=logo}
Experiments were done to determine if age-related changes occur in autonomic regulation of rat urinary bladder. The maximum contractile responses to acetylcholine were 63% and 15% greater in isolated bladders from 29-month and 17-month animals, respectively, as compared to 7-month animals. The amounts of [3H]quinuclidinyl benzilate bound to membrane preparations were 46% and 7% greater. In contrast, no age-related changes were observed in phenylephrine-induced contraction or in isoproterenol-induced relaxation of bladder. Thus, the urinary bladder of aged rats appears to develop increased sensitivity to cholinergic stimuli because of an increase in the number of muscarinic cholinergic receptors.
M G Kolta, and
L J Wallace, and
M C Gerald
January 1993,
Neurourology and urodynamics,
M G Kolta, and
L J Wallace, and
M C Gerald
May 2007,
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience,
M G Kolta, and
L J Wallace, and
M C Gerald
September 1981,
Journal of gerontology,
M G Kolta, and
L J Wallace, and
M C Gerald
December 1989,
Nihon Heikatsukin Gakkai zasshi,
M G Kolta, and
L J Wallace, and
M C Gerald
March 2016,
Journal of clinical and diagnostic research : JCDR,
M G Kolta, and
L J Wallace, and
M C Gerald
January 1986,
Der Internist,
M G Kolta, and
L J Wallace, and
M C Gerald
July 1975,
Experientia,
M G Kolta, and
L J Wallace, and
M C Gerald
February 1984,
Archives internationales de pharmacodynamie et de therapie,
M G Kolta, and
L J Wallace, and
M C Gerald
January 1997,
Arkhiv patologii,
M G Kolta, and
L J Wallace, and
M C Gerald
March 1980,
Journal of gerontology,
